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Drug-induced parkinsonism: Revisiting the epidemiology using the WHO pharmacovigilance database.
Parkinsonism & Related Disorders ( IF 4.1 ) Pub Date : 2019-12-17 , DOI: 10.1016/j.parkreldis.2019.12.011 Sibylle de Germay 1 , François Montastruc 1 , Alfonso Carvajal 2 , Maryse Lapeyre-Mestre 1 , Jean-Louis Montastruc 1
Parkinsonism & Related Disorders ( IF 4.1 ) Pub Date : 2019-12-17 , DOI: 10.1016/j.parkreldis.2019.12.011 Sibylle de Germay 1 , François Montastruc 1 , Alfonso Carvajal 2 , Maryse Lapeyre-Mestre 1 , Jean-Louis Montastruc 1
Affiliation
INTRODUCTION
Drug-Induced Parkinsonism (DIP) is the second most common cause of parkinsonism after idiopathic Parkinson's disease. Little is known about DIP epidemiology. Using VigiBase®, the objective of this study was to assess the main characteristics of DIP reporting around the world.
METHODS
We described reports recorded in the WHO pharmacovigilance database, Vigibase® and classified as "Parkinsonism" between 2000 and 2017. Differences of reporting between geographical locations and characteristics of reports were investigated using disproportionality analysis with calculation of Reporting Odds Ratios (ROR) and its 95% confidence interval.
RESULTS
Among the 9,009,107 reports recorded in VigiBase®, 4565 (0.05%) were DIP. Co reported terms were mainly "tremor" (n = 408, 8.9%), "gait disturbance" (n = 209, 4.6%) and "extrapyramidal disorders" (n = 180, 3.9%). DIP reports were significantly more frequent in men (ROR = 1.4; 95% CI 1.3-1.5) and in patients aged 75 and over (ROR = 2.12; 95% CI 1.98-2.26). Compared to all other continents, risk of reporting drug-induced parkinsonism was higher in Europe (ROR = 2.89; 95% CI 2.73-3.07), Africa (ROR = 1.81; 95% CI 1.46-2.25) and Oceania (ROR = 1.50; 95% CI 1.27-1.77). The risk was lower in Asia (ROR = 0.55; 95% CI 0.51-0.59) and America (ROR = 0.55 95% CI 0.51-0.59). The highest risk of DIP reporting was found with sulpiride and haloperidol followed by risperidone, aripiprazole, paliperidone, metoclopramide, olanzapine, quetiapine and clozapine.
CONCLUSION
Risk of DIP reports was higher in men, in people aged 75 and over and in Europe. Main drugs involved are antipsychotics not only drugs from the first generation but also those from the second one.
中文翻译：
药物诱发的帕金森综合症：使用WHO药物警戒数据库重新研究流行病学。
简介药物诱发的帕金森病（DIP）是继特发性帕金森氏病之后的第二个最常见的帕金森病病因。关于DIP流行病学知之甚少。使用VigiBase®，本研究的目的是评估全球DIP报告的主要特征。方法我们描述了2000年至2017年之间记录在WHO药物警戒数据库Vigibase®中的报告，归类为“帕金森氏病”。使用不成比例分析并计算报告几率（ROR）来研究报告地理位置和报告特征之间的差异。置信区间为95％。结果VigiBase®记录的9,009,107报告中有4565（0.05％）是DIP。共同报告的术语主要是“震颤”（n = 408，8.9％），“步态障碍”（n = 209，4）。6％）和“锥体外系疾病”（n = 180，3.9％）。男性（ROR = 1.4; 95％CI 1.3-1.5）和75岁及以上患者（ROR = 2.12; 95％CI 1.98-2.26）的DIP报告明显更高。与所有其他大洲相比，欧洲（ROR = 2.89; 95％CI 2.73-3.07），非洲（ROR = 1.81; 95％CI 1.46-2.25）和大洋洲（ROR = 1.50; 95％CI 1.27-1.77）。亚洲（ROR = 0.55; 95％CI 0.51-0.59）和美国（ROR = 0.55 95％CI 0.51-0.59）的风险较低。DIP报告的最高风险发现是舒必利和氟哌啶醇，其次是利培酮，阿立哌唑，帕潘立酮，甲氧氯普胺，奥氮平，喹硫平和氯氮平。结论DIP报告的风险在男性，75岁及以上的人群以及欧洲较高。
更新日期：2019-12-18
中文翻译：
药物诱发的帕金森综合症：使用WHO药物警戒数据库重新研究流行病学。
简介药物诱发的帕金森病（DIP）是继特发性帕金森氏病之后的第二个最常见的帕金森病病因。关于DIP流行病学知之甚少。使用VigiBase®，本研究的目的是评估全球DIP报告的主要特征。方法我们描述了2000年至2017年之间记录在WHO药物警戒数据库Vigibase®中的报告，归类为“帕金森氏病”。使用不成比例分析并计算报告几率（ROR）来研究报告地理位置和报告特征之间的差异。置信区间为95％。结果VigiBase®记录的9,009,107报告中有4565（0.05％）是DIP。共同报告的术语主要是“震颤”（n = 408，8.9％），“步态障碍”（n = 209，4）。6％）和“锥体外系疾病”（n = 180，3.9％）。男性（ROR = 1.4; 95％CI 1.3-1.5）和75岁及以上患者（ROR = 2.12; 95％CI 1.98-2.26）的DIP报告明显更高。与所有其他大洲相比，欧洲（ROR = 2.89; 95％CI 2.73-3.07），非洲（ROR = 1.81; 95％CI 1.46-2.25）和大洋洲（ROR = 1.50; 95％CI 1.27-1.77）。亚洲（ROR = 0.55; 95％CI 0.51-0.59）和美国（ROR = 0.55 95％CI 0.51-0.59）的风险较低。DIP报告的最高风险发现是舒必利和氟哌啶醇，其次是利培酮，阿立哌唑，帕潘立酮，甲氧氯普胺，奥氮平，喹硫平和氯氮平。结论DIP报告的风险在男性，75岁及以上的人群以及欧洲较高。
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