Abstract In this paper we studied the fabrication of a family of new biodegradable SERS sensors using a gold coated zein film with inverted pyramid structures that we had fabricated previously and coupled it with deposition of gold, silver and silver-shelled-gold nanoparticles. The proximity and contact between the gold surface and the new added nanoparticles help create new hot spots, which enhance the SERS intensity. Rhodamine 6 G was used as the Raman active molecule to evaluate the SERS enhancement effect. Results revealed that different nanoparticles exhibit different SERS effects. Silver-shelled-gold nanoparticles gave the highest enhancement factor of 3 × 105 followed by silver and gold nanoparticles relative to a glass surface. The enhancement factor of the new silver-shelled-gold nanoparticle decorated platform with the best performance relative to the gold coated zein nanophotonic structures is 102, a remarkable improvement. This sensitivity improvement takes the newly developed zein based biodegradable SERS biosensor platform one step closer to non-biodegradable sensors.

中文翻译：

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一种新型的可生物降解 ESERS（增强型 SERS）平台，在金涂层玉米醇溶蛋白纳米光子结构上沉积 Au、Ag 和 Au/Ag 纳米颗粒，用于检测食品分析物

摘要 在本文中，我们研究了使用我们之前制造的具有倒金字塔结构的金涂层玉米醇溶蛋白薄膜制造一系列新型可生物降解 SERS 传感器，并将其与金、银和银壳金纳米颗粒的沉积相结合。金表面与新添加的纳米粒子之间的接近和接触有助于产生新的热点，从而增强 SERS 强度。罗丹明6G被用作拉曼活性分子来评估SERS增强效果。结果表明，不同的纳米颗粒表现出不同的 SERS 效应。相对于玻璃表面，银壳金纳米粒子的增强因子最高，为 3 × 105，其次是银和金纳米粒子。与镀金玉米蛋白纳米光子结构相比，具有最佳性能的新型银壳金纳米粒子装饰平台的增强因子为 102，这是一个显着的改进。这种灵敏度的提高使新开发的基于玉米醇溶蛋白的可生物降解 SERS 生物传感器平台更接近于不可生物降解的传感器。