Abstract Recent research has contributed to advances in the treatment and prevention of colorectal cancer (CRC); however, the prevalence and mortality rate remain high. Lactococcus lactis subps. lactis is commonly used for industrial purposes, but there are no in vivo studies evaluating its anticarcinogenic potential. This study aimed to explore the protective effects of an isolate of L. lactis subsp. lactis (R7) from ricotta on CRC as well as evaluatingbiochemical and hematological parameters resulting from treatment. Wistar rats received subcutaneous doses of 1,2-dimethylhydrazine (DMH), what is a chemical carcinogen known to induce this carcinogenesis in experimental models, orally a suspension of R7 (108 colony-forming units. mL−1) and a hypercaloric diet. The results demonstrated a positive effect on the stabilization of the cancer cells induced in the colorectal epithelium, demonstrating anti-carcinogenic potential of R7 against CRC. In addition, an immune response was observed and the biochemical parameters showed that R7 reversed the stress caused by DMH and a hypercaloric diet. The results are promising as regards the behavior of R7 in relation to the treatment of CRC.

中文翻译：

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乳酸乳球菌亚种的体内作用。乳酸菌分离物 (R7) 具有益生菌潜力，可稳定结直肠上皮中的癌细胞

摘要 最近的研究促进了结直肠癌 (CRC) 的治疗和预防。然而，流行率和死亡率仍然很高。乳酸乳球菌亚种。乳酸菌通常用于工业用途，但没有评估其抗癌潜力的体内研究。本研究旨在探索乳酸乳球菌分离株的保护作用。来自 ricotta 的乳酸菌 (R7) 对 CRC 以及评估治疗产生的生化和血液学参数。Wistar 大鼠接受皮下剂量的 1,2-二甲基肼 (DMH)，这是一种已知在实验模型中诱导这种致癌作用的化学致癌物，口服 R7 悬浮液（108 个集落形成单位。mL-1）和高热量饮食。结果证明了对在结直肠上皮中诱导的癌细胞的稳定化有积极作用，证明了 R7 对 CRC 的抗癌潜力。此外，观察到免疫反应，生化参数显示 R7 逆转了 DMH 和高热量饮食引起的压力。就 R7 与 CRC 治疗相关的行为而言，结果是有希望的。