Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.

中文翻译：

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病毒诱导的干扰素调节尿素循环。

整合转录组学，蛋白质组学和代谢组学数据，Lercher等。在LCMV感染的小鼠模型中显示，I型干扰素会改变肝细胞中尿素循环关键酶的表达和功能。这导致全身代谢改变，减弱了抗病毒T细胞反应并减轻了肝损伤。