In a recent issue of Nature, Zhang et al. (2019) describe an additional histone post-translational modification, named histone lactylation. Following increased lactate production as a consequence of M1 polarization, histone lactylation regulates the induction of an M2-like phenotype in late stages of M1 macrophage activation to promote wound healing.

中文翻译：

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甜蜜的诱惑：从糖代谢到基因调控。

在《自然》杂志的最新一期中，Zhang等人。（2019）描述了另外的组蛋白翻译后修饰，称为组蛋白乳酰化。由于M1极化导致乳酸产生增加，组蛋白的乳酸化作用在M1巨噬细胞活化的后期调节M2类表型的诱导，从而促进伤口愈合。