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SGLT2 inhibitors to prevent diabetic kidney disease.
The Lancet Diabetes & Endocrinology ( IF 44.0 ) Pub Date : 2020-01-01 , DOI: 10.1016/s2213-8587(19)30387-0
Paola Fioretto 1 , Roberto Vettor 1 , Roberto Pontremoli 2
Affiliation  

Up to 40% of patients with type 2 diabetes develop diabetic kidney disease, presenting with increased albuminuria (urinary albumin-to-creatinine ratio [UACR]), decreased glomerular filtration rate (GFR), or both. Unfortunately, there is no reliable method to predict who will eventually develop diabetic kidney disease and by the time increased albuminuria or reduction in GFR are detected, the burden of renal and cardiovascular risk is already high. Despite standard recommended care, including optimal control of blood pressure, glucose, and lipids, and use of renin–angiotensin system (RAS) blockade, residual risk of progression remains high in people with type 2 diabetes, and diabetic kidney disease is currently the leading cause of end-stage kidney disease (ESKD) worldwide.

中文翻译:

SGLT2抑制剂可预防糖尿病肾病。

多达40%的2型糖尿病患者发展为糖尿病肾病,表现为白蛋白尿增加(尿白蛋白与肌酐比值[UACR]),肾小球滤过率(GFR)降低或两者兼有。不幸的是,没有可靠的方法来预测谁最终会患上糖尿病性肾脏疾病,并且到检测出白蛋白尿增加或GFR降低时,肾脏和心血管疾病的负担已经很高。尽管推荐了标准的护理措施,包括最佳控制血压,葡萄糖和脂质,以及使用肾素-血管紧张素系统(RAS)阻滞剂,但2型糖尿病患者的残余进展风险仍然很高,而糖尿病肾病目前是领先的世界范围内终末期肾脏疾病(ESKD)的病因。
更新日期:2019-12-18
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