There is a great interest in exploring the mechanisms of oedema in nephrotic syndrome (NS) as evidenced by 2 parallel studies published in Acta Physiologica (1, 2). This has generated an editorial comment (3) which we respond to by this rebuttal. The interest in the nephrotic edema reflects not only the significant negative impact this has on the quality of life, but also the difficulties associated with identifying optimal treatment due to the lack of pathophysiological insight.

中文翻译：

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uPA-纤溶酶-ENaC在肾病综合征中的钠retention留-作者回复。

在《 Acta Physiologica》上发表的2篇并行研究证明了对探索肾病综合征（NS）水肿机制的浓厚兴趣（1，2）。这产生了社论评论（3），我们通过这种反驳对此做出回应。对肾病性水肿的兴趣不仅反映了其对生活质量的重大负面影响，而且反映了由于缺乏病理生理学见识而无法确定最佳治疗方法的困难。