当前位置: X-MOL 学术Nat. Rev. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Neuroimmune circuits in inter-organ communication.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-12-17 , DOI: 10.1038/s41577-019-0247-z
Jun R Huh 1, 2 , Henrique Veiga-Fernandes 3
Affiliation  

Studies in recent years have uncovered the crucial function of neuroimmune interactions in maintaining tissue homeostasis and protection. Immune and neuronal cells are often colocalized at defined anatomical sites, forming neuroimmune cell units, where both cell types coordinate their responses. In addition, even when located at distant sites, neuronal cells can receive signals from and provide signals to peripheral immune cells. As such, neuroimmune interactions are found across multiple organs and have recently emerged as important regulators of physiology. In this Review, we focus on the impact of bidirectional neuroimmune interactions in tissue biology, organ physiology and embryonic development. Finally, we explore how this fast-evolving field is redefining the tenets of inter-organ and intergenerational communications.

中文翻译:

器官间通讯中的神经免疫回路。

近年来的研究发现了神经免疫相互作用在维持组织稳态和保护中的关键作用。免疫细胞和神经元细胞通常共存于确定的解剖部位,形成神经免疫细胞单元,其中两种细胞类型协调它们的反应。此外,即使位于遥远的位置,神经元细胞也可以从周围的免疫细胞接收信号并向周围的免疫细胞提供信号。这样,在多个器官之间发现了神经免疫相互作用,并且最近已成为重要的生理调节剂。在这篇综述中,我们着眼于双向神经免疫相互作用对组织生物学,器官生理学和胚胎发育的影响。最后,我们探讨了这个快速发展的领域如何重新定义了器官间和世代间交流的宗旨。
更新日期:2019-12-18
down
wechat
bug