Targeting innate sensing in the tumor microenvironment to improve immunotherapy.,Cellular & Molecular Immunology

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Targeting innate sensing in the tumor microenvironment to improve immunotherapy.
Cellular & Molecular Immunology ( IF 21.8 ) Pub Date : 2019-12-16 , DOI: 10.1038/s41423-019-0341-y
Zhida Liu ₁ , Chuanhui Han ₁ , Yang-Xin Fu _{1,

2}

Affiliation

The innate immune sensing pathways play critical roles in the defense against pathogen infection, but their roles in cancer immunosurveillance and cancer therapies are less defined. We propose that defective innate immune sensing inside the tumor microenvironment might limit T-cell responses to immunotherapy. A recent mechanistic understanding of conventional therapies revealed that both innate immune sensing and T-cell responses are essential for optimal antitumor efficacy. T-cell-based immunotherapy, particularly immune checkpoint blockade, has achieved great success in reactivating antitumor immune responses to lead to tumor regression, but only in a small fraction of patients. Therefore, incorporating conventional therapy that can increase innate sensing and immunotherapy should lead to promising strategies for cancer patients. Here, we review the innate sensing pathways related to cancer initiation/progression and therapies, summarize the recent key findings in innate immune sensing related to conventional therapies, evaluate current combination strategies, and highlight the potential issues of combinational therapies in terms of antitumor efficacy and toxicities.

中文翻译：

靶向肿瘤微环境中的先天感知以改善免疫治疗。

先天免疫传感通路在防御病原体感染中发挥关键作用，但它们在癌症免疫监视和癌症治疗中的作用尚不明确。我们提出，肿瘤微环境内有缺陷的先天免疫感应可能会限制 T 细胞对免疫治疗的反应。最近对传统疗法的机制理解表明，先天免疫感应和 T 细胞反应对于最佳抗肿瘤功效至关重要。基于 T 细胞的免疫疗法，尤其是免疫检查点阻断，在重新激活抗肿瘤免疫反应以导致肿瘤消退方面取得了巨大成功，但仅限于一小部分患者。因此，结合可以增加先天感知和免疫疗法的传统疗法应该会为癌症患者带来有希望的策略。这里，

更新日期：2019-12-17

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