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Twin-peak temporal regulation during human neocortical development.
Cell Discovery ( IF 13.0 ) Pub Date : 2019-12-17 , DOI: 10.1038/s41421-019-0129-3 Wei Wang 1 , Guang-Zhong Wang 1
Cell Discovery ( IF 13.0 ) Pub Date : 2019-12-17 , DOI: 10.1038/s41421-019-0129-3 Wei Wang 1 , Guang-Zhong Wang 1
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Understanding the temporal and spatial expression patterns of the human cerebral cortex is essential for expanding knowledge of its functionality. Previous analysis focused on the differentially expressed genes (DEGs) among cortical subregions revealed an hourglass model for interareal differences. However, the overall pattern of transcriptional differences during the development of every region remains to be fully explored. Here, analysing more than 800 neocortex samples from lifespan transcriptional profiles revealed that excitatory neurons are more regulated than inhibitory neurons in the foetal brain. Developmental DEGs tend to be resting state or memory encoding-related and are also involved in autism and Alzheimer's disease. In addition, twin peaks of DEGs occur during the development of each neocortex region, with a first peak appearing in the perinatal period and an unexpected second peak appearing around childhood. Genes in these peaks have similar functions, but the second peak is more inhibitory neuron related. All these results emphasize the significance of this unique temporal regulatory pattern for human neocortical development.
中文翻译：
人类新皮层发育过程中的双峰时间调节。
了解人类大脑皮层的时空表达模式对于扩展对其功能的认识至关重要。先前针对皮质子区域之间差异表达基因（DEG）的分析揭示了区域间差异的沙漏模型。但是，每个区域发育过程中转录差异的整体模式仍有待充分探讨。在这里，从寿命转录谱分析了800多个新皮层样本，发现在胎儿大脑中，兴奋性神经元比抑制性神经元受到更多的调节。发育性DEG往往与静止状态或记忆编码有关，并且还与自闭症和阿尔茨海默氏病有关。此外，每个新皮质区域的形成过程中都会出现DEG的双峰，第一个高峰出现在围产期，出乎意料的第二个高峰出现在儿童时期。这些峰中的基因具有相似的功能，但第二个峰与抑制神经元的相关性更高。所有这些结果强调了这种独特的时间调节模式对人类新皮层发育的重要性。
更新日期：2019-12-17
中文翻译：
人类新皮层发育过程中的双峰时间调节。
了解人类大脑皮层的时空表达模式对于扩展对其功能的认识至关重要。先前针对皮质子区域之间差异表达基因（DEG）的分析揭示了区域间差异的沙漏模型。但是，每个区域发育过程中转录差异的整体模式仍有待充分探讨。在这里，从寿命转录谱分析了800多个新皮层样本，发现在胎儿大脑中，兴奋性神经元比抑制性神经元受到更多的调节。发育性DEG往往与静止状态或记忆编码有关，并且还与自闭症和阿尔茨海默氏病有关。此外，每个新皮质区域的形成过程中都会出现DEG的双峰，第一个高峰出现在围产期，出乎意料的第二个高峰出现在儿童时期。这些峰中的基因具有相似的功能，但第二个峰与抑制神经元的相关性更高。所有这些结果强调了这种独特的时间调节模式对人类新皮层发育的重要性。
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