Degeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes. With the advancement in our knowledge about the mechanisms that regulate the development of the vertebrate retina, the approach to treat blinding diseases through regenerative medicine appears a near possibility. Recapitulation of developmental mechanisms is critical for reproducibly generating cells in either 2D or 3D culture of pluripotent stem cells for retinal repair and disease modeling. It is the key for unlocking the neurogenic potential of Müller glia in the adult retina for therapeutic regeneration. Here, we examine the current status and potential of the regenerative medicine approach for the retina in the backdrop of developmental mechanisms.

青光眼，年龄相关性黄斑变性和色素性视网膜炎等疾病中特定视网膜神经元的变性是不可逆性失明的主要原因。目前，尚无疗法可改变与疾病相关的退行性改变。随着我们对调节脊椎动物视网膜发育的机制的认识的提高，通过再生医学治疗致盲疾病的方法似乎成为可能。对于视网膜修复和疾病建模，多能干细胞的2D或3D培养中可再生地生成细胞的发展机制的概述至关重要。这是释放成年视网膜中Müller胶质神经源性潜力以进行治疗性再生的关键。这里，