Non-transdermal microneedles for advanced drug delivery.,Advanced Drug Delivery Reviews

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Non-transdermal microneedles for advanced drug delivery.
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2019-12-16 , DOI: 10.1016/j.addr.2019.11.010
KangJu Lee ₁ , Marcus J Goudie ₁ , Peyton Tebon ₁ , Wujin Sun ₁ , Zhimin Luo ₁ , Junmin Lee ₁ , Shiming Zhang ₁ , Kirsten Fetah ₁ , Han-Jun Kim ₁ , Yumeng Xue ₁ , Mohammad Ali Darabi ₁ , Samad Ahadian ₁ , Einollah Sarikhani ₁ , WonHyoung Ryu ₂ , Zhen Gu ₃ , Paul S Weiss ₄ , Mehmet R Dokmeci ₅ , Nureddin Ashammakhi ₅ , Ali Khademhosseini ₆

Affiliation

Department of Bioengineering and Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA 90095, USA; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Department of Mechanical Engineering, Yonsei University, Seoul 03722, South Korea.
Department of Bioengineering and Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA 90095, USA; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90024, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
Department of Bioengineering and Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA 90095, USA; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Chemistry and Biochemistry, Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Radiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Department of Bioengineering and Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA 90095, USA; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Radiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Microneedles (MNs) have been used to deliver drugs for over two decades. These platforms have been proven to increase transdermal drug delivery efficiency dramatically by penetrating restrictive tissue barriers in a minimally invasive manner. While much of the early development of MNs focused on transdermal drug delivery, this technology can be applied to a variety of other non-transdermal biomedical applications. Several variations, such as multi-layer or hollow MNs, have been developed to cater to the needs of specific applications. The heterogeneity in the design of MNs has demanded similar variety in their fabrication methods; the most common methods include micromolding and drawing lithography. Numerous materials have been explored for MN fabrication which range from biocompatible ceramics and metals to natural and synthetic biodegradable polymers. Recent advances in MN engineering have diversified MNs to include unique shapes, materials, and mechanical properties that can be tailored for organ-specific applications. In this review, we discuss the design and creation of modern MNs that aim to surpass the biological barriers of non-transdermal drug delivery in ocular, vascular, oral, and mucosal tissue.

中文翻译：

用于先进药物输送的非透皮微针。

微针（MN）用于输送药物已有二十多年的历史。这些平台已被证明可以通过以微创方式穿透限制性组织屏障来显着提高透皮药物输送效率。虽然 MN 的早期开发大部分集中于透皮给药，但该技术可以应用于各种其他非透皮生物医学应用。为了满足特定应用的需求，已经开发了多种变体，例如多层或空心 MN。 MN 设计的异质性要求其制造方法具有相似的多样性；最常见的方法包括微成型和平版印刷。人们已经探索了许多用于 MN 制造的材料，从生物相容性陶瓷和金属到天然和合成的可生物降解聚合物。微神经工程的最新进展使微神经变得多样化，包括独特的形状、材料和机械性能，可以针对特定器官的应用进行定制。在这篇综述中，我们讨论了现代 MN 的设计和创建，旨在超越眼部、血管、口腔和粘膜组织中非透皮给药的生物屏障。

更新日期：2020-04-20

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