K2S2O8-HFIP synergistically promoted para-selective sp3 C-H bond diarylation of glycine esters.,Organic & Biomolecular Chemistry

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K2S2O8-HFIP synergistically promoted para-selective sp3 C-H bond diarylation of glycine esters.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-01-02 , DOI: 10.1039/c9ob02489a
Qingfeng Xu ₁ , Bang Li ₁ , Yujie Ma ₁ , Fei Sun ₁ , Yanan Gao ₁ , Na Ye ₁

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A metal-free K2S2O8-HFIP synergistically promoted double Friedel-Crafts alkylation between a glycine derivative and N-substituted aniline was developed to efficiently synthesize diarylmethane derivatives with high para-selectivity. The reaction proceeded smoothly in the absence of any metal and ligand, and exhibited a good tolerance of functional groups.

中文翻译：

K2S2O8-HFIP协同促进甘氨酸酯的对位选择性sp3 CH键二芳基化。

开发了一种无金属的K2S2O8-HFIP，可在甘氨酸衍生物和N-取代的苯胺之间协同促进双Friedel-Crafts烷基化反应，从而以高对位选择性有效地合成二芳基甲烷衍生物。在没有任何金属和配体的情况下，反应进行得很顺利，并且对官能团表现出良好的耐受性。

更新日期：2020-02-10

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