Stereoselective Michael additions on α-aminoacrylates as the key step to an l-Oic analogue bearing a quaternary stereocenter.,Organic & Biomolecular Chemistry

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Stereoselective Michael additions on α-aminoacrylates as the key step to an l-Oic analogue bearing a quaternary stereocenter.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-01-02 , DOI: 10.1039/c9ob02084e
Federico Maria Cecchinelli ₁ , Giuseppe Celentano ₁ , Alessandra Puglisi ₂ , Nicoletta Gaggero ₁

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A novel, highly stereoselective route for pharmaceutically relevant octahydroindole-2-carboxylates bearing a quaternary stereocenter has been developed. The key chiral intermediates 3 have been prepared in good yields and enantiomeric excesses up to 98%. A broad substrate range has been tolerated under the reaction conditions.

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