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Expanding the use of hepatitis C-positive donors and keeping recipient safety at the forefront.
American Journal of Transplantation ( IF 8.8 ) Pub Date : 2020-01-13 , DOI: 10.1111/ajt.15745
Norah A Terrault 1 , Linda Sher 2
Affiliation  

The opioid crisis, the need for more organs for all transplant candidates and the availability of effective direct acting antivirals (DAAs) for hepatitis C virus (HCV) have converged to bring transplants from HCV‐viremic donors to the forefront. While use of such organs in recipients with preexisting chronic HCV is well‐established, use in HCV negative patients is a newer phenomenon and requires delineation of the risks and benefits to wait‐listed patients and examination of programmatic and financial requirements to ultimately inform best practices for the transplant community.

中文翻译:

扩大丙型肝炎阳性捐献者的使用,并将接受者的安全放在首位。

阿片类药物危机、所有移植候选者对更多器官的需求以及针对丙型肝炎病毒 (HCV) 的有效直接作用抗病毒药物 (DAA) 的可用性已经汇聚在一起,将来自 HCV 病毒血症供体的移植带到了前沿。虽然在既往存在慢性 HCV 的接受者中使用此类器官已得到公认,但在 HCV 阴性患者中使用是一种较新的现象,需要描述等待名单患者的风险和益处,并检查计划和财务要求,以最终为最佳实践提供信息对于移植社区。
更新日期:2019-12-17
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