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The role of chromatin remodeling complexes in Schwann cell development.
Glia ( IF 5.4 ) Pub Date : 2019-12-14 , DOI: 10.1002/glia.23766
Franziska Fröb 1 , Michael Wegner 1
Affiliation  

Schwann cells develop from neural crest cells in an ordered series of events and give rise to myelinating and nonmyelinating subtypes. In their mature state, myelinating Schwann cells produce myelin sheaths that provide trophic support to axons and allow saltatory conduction in the vertebrate peripheral nervous system. Each step of Schwann cell development requires defined changes in chromatin structure that are catalyzed by chromatin remodeling complexes. Over the last years, all major types of chromatin remodeling complexes have been detected in Schwann cells and several have been functionally analyzed. SWI/SNF‐type, CHD‐type, and INO80/SWR‐type chromatin remodelers in particular have been shown to interact with multiple cell‐type specific transcription factors and histone modifiers and to be important regulators of Schwann cell development. As a result of different recruitment strategies, each chromatin remodeler targets defined genomic areas and impacts unique mechanisms at specific stages of Schwann cell development. Chromatin remodeling complexes undoubtedly constitute essential components of the Schwann cell regulatory network.

中文翻译:

染色质重塑复合物在雪旺细胞发育中的作用。

雪旺氏细胞在一系列有序的事件中从神经嵴细胞发育而来,并产生有髓鞘和无髓鞘亚型。在成熟状态下,有髓鞘的雪旺氏细胞产生髓鞘,为轴突提供营养支持并允许脊椎动物周围神经系统中的跳跃传导。雪旺氏细胞发育的每一步都需要染色质结构的明确变化,这些变化是由染色质重塑复合物催化的。在过去的几年里,在雪旺细胞中检测到了所有主要类型的染色质重塑复合物,并且已经对几种进行了功能分析。特别是 SWI/SNF 型、CHD 型和 INO80/SWR 型染色质重塑剂已被证明与多种细胞类型特异性转录因子和组蛋白修饰物相互作用,并且是雪旺细胞发育的重要调节剂。由于不同的招募策略,每个染色质重塑剂都针对定义的基因组区域,并在雪旺细胞发育的特定阶段影响独特的机制。染色质重塑复合物无疑构成了雪旺氏细胞调节网络的重要组成部分。
更新日期:2019-12-14
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