Metabolic correlates of dopaminergic loss in dementia with lewy bodies,Movement Disorders

当前位置： X-MOL 学术 › Mov. Disord. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Metabolic correlates of dopaminergic loss in dementia with lewy bodies
Movement Disorders ( IF 8.6 ) Pub Date : 2019-12-16 , DOI: 10.1002/mds.27945
Maria Huber ₁ , Leonie Beyer ₁ , Catharina Prix ₂ , Sonja Schönecker ₂ , Carla Palleis ₂ , Boris-Stephan Rauchmann _{3,

4} , Silvia Morbelli _{5,

6} , Andrea Chincarini ₇ , Rose Bruffaerts _{8,

9} , Rik Vandenberghe _{8,

9} , Koen Van Laere ₁₀ , Milica G Kramberger ₁₁ , Maja Trost _{11,

12} , Marko Grmek ₁₂ , Valentina Garibotto ₁₃ , Nicolas Nicastro _{14,

15} , Giovanni B Frisoni ₁₆ , Afina W Lemstra ₁₇ , Jessica van der Zande ₁₇ , Andrea Pilotto _{18,

19} , Alessandro Padovani ₁₈ , Sara Garcia-Ptacek _{20,

21} , Irina Savitcheva ₂₂ , Miguel A Ochoa-Figueroa _{23,

24,

25} , Anette Davidsson ₂₃ , Valle Camacho ₂₆ , Enrico Peira _{7,

27} , Dario Arnaldi _{5,

27} , Matteo Bauckneht _{5,

6} , Matteo Pardini _{5,

27} , Gianmario Sambuceti _{5,

6} , Jonathan Vöglein _{2,

28} , Jonas Schnabel ₁ , Marcus Unterrainer ₁ , Robert Perneczky _{3,

28,

29,

30} , Oliver Pogarell ₃ , Katharina Buerger _{28,

30} , Cihan Catak ₃₀ , Peter Bartenstein _{1,

31} , Paul Cumming _{32,

33} , Michael Ewers ₂₈ , Adrian Danek ₂ , Johannes Levin _{2,

28,

31} , Dag Aarsland _{34,

35} , Flavio Nobili _{5,

27} , Axel Rominger _{1,

31,

32} , Matthias Brendel _{1,

31}

Affiliation

Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Department of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Department of Radiology, University Hospital of Munich, LMU Munich, Munich, Germany.
IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Nuclear Medicine Unit, Department of Health Sciences, University of Genoa, Genoa, Italy.
National Institute of Nuclear Physics (INFN), Genoa section, Genoa, Genoa, Italy.
Department of Neurosciences, Faculty of Medicine, KU Leuven, Leuven, Belgium.
Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
Department of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium.
Department of Neurology, University Medical Centre, Ljubljana, Slovenia.
Department for Nuclear Medicine, University Medical Centre, Ljubljana, Slovenia.
Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals and NIMTLab, Geneva University, Geneva, Switzerland.
Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
LANVIE (Laboratoire de Neuroimagerie du Vieillissement), Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.
VU Medical Center Alzheimer Center, Amsterdam, The Netherlands.
Neurology Unit, University of Brescia, Brescia, Italy.
Parkinson's Disease Rehabilitation Centre, FERB ONLUS-S. Isidoro Hospital, Trescore Balneario (BG), Italy.
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Internal Medicine, section for Neurology, Sädersjukhuset, Stockholm, Sweden.
Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.
Department of Clinical Physiology, Institution of Medicine and Health Sciences, Linköping University Hospital, Linköping, Sweden.
Department of Diagnostic Radiology, Linköping University Hospital, Linköping, Sweden.
Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España.
Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
DZNE-German Center for Neurodegenerative Diseases, Munich, Germany.
Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College, London, United Kingdom.
Institut for Stroke and Dementia Research, University of Munich, Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Department of Nuclear Medicine, University of Bern, Inselspital, Bern, Switzerland.
School of Psychology and Counselling and IHBI, Queensland University of Technology, Brisbane, Australia.
Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.
Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.

Striatal dopamine deficiency and metabolic changes are well‐known phenomena in dementia with Lewy bodies and can be quantified in vivo by 123I‐Ioflupane brain single‐photon emission computed tomography of dopamine transporter and 18F‐fluorodesoxyglucose PET. However, the linkage between both biomarkers is ill‐understood.

中文翻译：