Abstract

Background

Nasopharyngeal carcinoma (NPC) has distinct histopathology and associated with high mortality rate. Identification of NPC cases that have aggressive behavior at an early-stage can aid in improvement of the survival. Assessment of tumor-infiltrating lymphocytes (TILs) has shown a promising prognostic value in many epithelial cancers.

Methods

This study included a multicenter cohort of 44 cases treated for early-stage (I-II) NPC at the five Finnish university hospitals (Helsinki, Turku, Tampere, Kuopio and Oulu). Hematoxylin and eosin-stained cancer sections were used to evaluate TILs. We followed the guidelines that recently introduced by International Immuno-Oncology Biomarkers Working Group for assessment of TILs in different tumors including head and neck cancer.

Results

The score of intra-tumoral TILs showed a promising prognostic value for predicting survival in early NPC. A hazard ratio of 2.45 and 95% confidence interval of 1.07 to 5.62 (P = 0.03) was reported, indicates that tumors with low TILs have a higher risk of mortality.

Conclusion

In early-stage of NPC, assessment of TILs has a significant prognostic value that can be useful to identify cases with aggressive behavior. Further studies are necessary to validate the importance of TILs in larger cohorts of early NPC.

Legal entity responsible for the study

Alhadi Almangush.

Funding

Has not received any funding.

Disclosure

The author has declared no conflicts of interest.

中文翻译：

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9P早期鼻咽癌肿瘤浸润淋巴细胞的总体评估

抽象的

背景

鼻咽癌（NPC）具有独特的组织病理学特征，并具有较高的死亡率。早期识别具有侵略性行为的NPC病例可以帮助提高生存率。肿瘤浸润淋巴细胞（TIL）的评估已显示出在许多上皮癌中有希望的预后价值。

方法

这项研究包括在芬兰的五所大学医院（赫尔辛基，图尔库，坦佩雷，库奥皮奥和奥卢）治疗早期（I-II）NPC的44例多中心队列。将苏木精和伊红染色的癌切片用于评估TIL。我们遵循了国际免疫肿瘤生物标记物工作组最近引入的指南，用于评估包括头颈癌在内的不同肿瘤中的TIL。

结果

肿瘤内TILs评分显示出可预测NPC早期生存的预后价值。据报道，危险比为2.45，95％的置信区间为1.07至5.62（P = 0.03），表明低TILs的肿瘤具有更高的死亡风险。

结论

在NPC的早期阶段，对TIL的评估具有重要的预后价值，可用于识别具有攻击性行为的病例。有必要进行进一步的研究以验证TIL在早期NPC的较大人群中的重要性。

负责研究的法人实体

Alhadi Almangush。

资金

尚未收到任何资金。

揭露

作者宣称没有利益冲突。