Palladium‐Catalyzed Decarboxylative Synthesis of 5H‐Benzo[4,5][1,3]oxazino[2,3‐a]isoindole‐5,11(6aH)‐Diones using 2‐Phenyl‐4H‐Benzo[d][1,3]oxazin‐4‐Ones and α‐Oxo Carboxylic Acids,Advanced Synthesis & Catalysis

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Palladium‐Catalyzed Decarboxylative Synthesis of 5H‐Benzo[4,5][1,3]oxazino[2,3‐a]isoindole‐5,11(6aH)‐Diones using 2‐Phenyl‐4H‐Benzo[d][1,3]oxazin‐4‐Ones and α‐Oxo Carboxylic Acids
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-01-07 , DOI: 10.1002/adsc.201901142
Ram Sunil Kumar Lalji _{1,

2} , Prashant Kumar _{1,

3} , Mohit Gupta _{1,

4} , Virinder S. Parmar _{1,

5} , Brajendra K. Singh ₁

Affiliation

A Pd‐catalyzed novel and efficient protocol has been developed for the direct functionalization of 2‐phenyl‐4H‐benzo[d][1,3]oxazin‐4‐ones with α‐oxo carboxylic acids resulting in 5H‐benzo[4,5][1,3]oxazino[2,3‐a]isoindole‐5,11(6aH)‐diones using (NH₄)₂S₂O₈ as effective oxidant and AgNO₃ as co‐oxidant. All the explored substrates were found to be compatible for this transformation and delivered the corresponding desired products in moderate to excellent yields.

中文翻译：

使用2-苯基-4H-苯并[d] [1]钯催化脱羧合成5H-苯并[4,5] [1,3]恶嗪基[2,3-a]异吲哚-5,11（6aH）-二酮，3]恶嗪-4-酮和α-氧代羧酸

已开发出一种Pd催化的新颖有效的方案，可将2-苯基-4- H-苯并[ d ] [1,3]恶嗪-4-酮与α-氧代羧酸直接官能化，生成5 H-苯并[ 4,5] [1,3]恶嗪基[2,3 - a ]异吲哚-5,11 （6a H）-二酮使用（NH ₄）₂ S ₂ O ₈作为有效氧化剂，AgNO ₃作为共氧化剂。发现所有探索的底物均适用于该转化，并以中等至优异的产率递送了相应的所需产物。

更新日期：2020-01-07

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