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Palladium‐Catalyzed Decarboxylative Synthesis of 5H‐Benzo[4,5][1,3]oxazino[2,3‐a]isoindole‐5,11(6aH)‐Diones using 2‐Phenyl‐4H‐Benzo[d][1,3]oxazin‐4‐Ones and α‐Oxo Carboxylic Acids
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-01-07 , DOI: 10.1002/adsc.201901142
Ram Sunil Kumar Lalji 1, 2 , Prashant Kumar 1, 3 , Mohit Gupta 1, 4 , Virinder S. Parmar 1, 5 , Brajendra K. Singh 1
Affiliation  

A Pd‐catalyzed novel and efficient protocol has been developed for the direct functionalization of 2‐phenyl‐4H‐benzo[d][1,3]oxazin‐4‐ones with α‐oxo carboxylic acids resulting in 5H‐benzo[4,5][1,3]oxazino[2,3‐a]isoindole‐5,11(6aH)‐diones using (NH4)2S2O8 as effective oxidant and AgNO3 as co‐oxidant. All the explored substrates were found to be compatible for this transformation and delivered the corresponding desired products in moderate to excellent yields.

中文翻译:

使用2-苯基-4H-苯并[d] [1]钯催化脱羧合成5H-苯并[4,5] [1,3]恶嗪基[2,3-a]异吲哚-5,11(6aH)-二酮,3]恶嗪-4-酮和α-氧代羧酸

已开发出一种Pd催化的新颖有效的方案,可将2-苯基-4- H-苯并[ d ] [1,3]恶嗪-4-酮与α-氧代羧酸直接官能化,生成5 H-苯并[ 4,5] [1,3]恶嗪基[2,3 - a ]异吲哚-5,11 (6a H)-二酮使用(NH 42 S 2 O 8作为有效氧化剂,AgNO 3作为共氧化剂。发现所有探索的底物均适用于该转化,并以中等至优异的产率递送了相应的所需产物。
更新日期:2020-01-07
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