Carbon dots: a booming material for biomedical applications,Materials Chemistry Frontiers

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Carbon dots: a booming material for biomedical applications
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2019/12/14 , DOI: 10.1039/c9qm00658c
Wen Su _{1,

2,

3,

4,

5} , Hao Wu _{1,

2,

3,

4,

5} , Huimin Xu _{1,

2,

3,

4,

5} , Yang Zhang _{1,

2,

3,

4,

5} , Yunchao Li _{1,

2,

3,

4,

5} , Xiaohong Li _{1,

2,

3,

4,

5} , Louzhen Fan _{1,

2,

3,

4,

5}

Affiliation

As one of the most promising nanomaterials for biomedical applications, carbon dots (CDs) hold great potential in the field of bioimaging, biosensing and biotherapy due to their low cytotoxicity, high water solubility, favorable biocompatibility, good photostability, tunable fluorescence emission and excitation. In this review, we will provide an update on the latest research of CDs on the synthetic routes, chemical modifications, optical properties and biomedical applications. We will mainly discuss their applications in bioimaging of normal and cancer stem cells and tumour cells, two-photon fluorescence imaging, in vivo imaging, biosensing, and cancer therapy including photothermal therapy, photodynamic therapy and chemotherapy. At the end, current challenges and future perspectives of CDs in biomedical applications will also be discussed. We hope that this review will provide valuable insights to inspire new discoveries on CDs and draw a roadmap towards a broader range of biomedical applications.

中文翻译：

碳点：一种用于生物医学应用的新兴材料

作为生物医学应用中最有前途的纳米材料之一，碳点（CD）具有低细胞毒性，高水溶性，良好的生物相容性，良好的光稳定性，可调节的荧光发射和激发等优点，在生物成像，生物传感和生物治疗领域具有巨大的潜力。在这篇评论中，我们将提供CD的最新研究的最新进展，这些CD涉及合成路线，化学修饰，光学性质和生物医学应用。我们将主要讨论它们在正常和癌症干细胞和肿瘤细胞的生物成像，双光子荧光成像，体内的应用成像，生物传感和癌症治疗，包括光热疗法，光动力疗法和化学疗法。最后，还将讨论CD在生物医学应用中的当前挑战和未来前景。我们希望这篇评论将提供宝贵的见解，以激发CD上的新发现，并为更广泛的生物医学应用制定路线图。

更新日期：2020-03-05

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