A new study links pathogenic cubilin gene (CUBN) variants to proteinuria without progressive renal impairment, providing reassurance for a subset of patients, calling into question the accepted pathogenesis of glomerulosclerosis and suggesting future therapeutic options.

中文翻译：

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CUBN变体使蛋白尿与肾脏功能脱钩。

一项新研究将致病性cubicin基因（CUBN）变体与蛋白尿相关联，而无进行性肾功能不全，为部分患者提供了保证，质疑肾小球硬化的公认发病机制，并提出了未来的治疗选择。