Metastasis contributes to the vast majority of cancer-related mortality. Regulatory mechanisms of the multistep invasion-metastasis cascade are being unraveled. TP53 is the most frequently mutated gene across human cancers. Accumulating evidence has shown that mutations of TP53 not only lead to loss of function or dominant negative effects, but also promotes a gain of function. Specifically, gain of function mutant p53 promotes cancer cell motility, invasion, and metastasis. Here, we summarize the mechanisms and functions of mutant p53 that foster metastasis in different types of cancers. We also discuss the prognostic value of mutant p53 and current status of therapeutic strategies targeting mutant p53. Future studies will shed light on discovering novel mechanisms of mutant p53-driven cancer metastasis and developing innovative therapeutics to improve clinical outcomes in patients harboring p53 mutations.

转移导致绝大多数与癌症相关的死亡。多步骤侵袭转移级联的调节机制正在阐明。TP53是人类癌症中最常见的突变基因。越来越多的证据表明TP53的突变不仅导致功能丧失或显性负作用，而且还促进了功能的获得。具体而言，功能突变体p53的获得促进癌细胞的运动性，侵袭和转移。在这里，我们总结了促进不同类型癌症转移的突变体p53的机制和功能。我们还讨论了突变体p53的预后价值和靶向突变体p53的治疗策略的现状。未来的研究将为发现突变的p53驱动的癌症转移的新机制以及开发创新的疗法以改善具有p53突变的患者的临床结局提供新的思路。