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Dopamine fuels its own release.
Nature Neuroscience ( IF 25.0 ) Pub Date : 2020-01-01 , DOI: 10.1038/s41593-019-0563-4
Rongmin Chen 1 , Elizabeth A Jonas 1, 2
Affiliation  

A new study shows that the enzyme monoamine oxidase funnels a byproduct of dopamine metabolism, H2O2, directly into the mitochondrial electron transport chain, stimulating ATP production. This alternative energy pathway may protect dopaminergic neurons from the toxicity induced by dopamine metabolism while supporting phasic firing.

中文翻译:

多巴胺促进自身释放。

一项新的研究表明,单胺氧化酶将多巴胺代谢的副产物 H2O2 直接输送到线粒体电子传递链中,从而刺激 ATP 的产生。这种替代能量通路可以保护多巴胺能神经元免受多巴胺代谢诱导的毒性,同时支持阶段性放电。
更新日期:2019-12-17
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