Prefrontal somatostatin interneurons encode fear memory.,Nature Neuroscience

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Prefrontal somatostatin interneurons encode fear memory.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2019-12-16 , DOI: 10.1038/s41593-019-0552-7
Kirstie A Cummings ₁ , Roger L Clem ₁

Affiliation

Theories stipulate that memories are encoded within networks of cortical projection neurons. Conversely, GABAergic interneurons are thought to function primarily to inhibit projection neurons and thereby impose network gain control, an important but purely modulatory role. Here we show in male mice that associative fear learning potentiates synaptic transmission and cue-specific activity of medial prefrontal cortex somatostatin (SST) interneurons and that activation of these cells controls both memory encoding and expression. Furthermore, the synaptic organization of SST and parvalbumin interneurons provides a potential circuit basis for SST interneuron-evoked disinhibition of medial prefrontal cortex output neurons and recruitment of remote brain regions associated with defensive behavior. These data suggest that, rather than constrain mnemonic processing, potentiation of SST interneuron activity represents an important causal mechanism for conditioned fear.

中文翻译：

前额生长抑素中间神经元编码恐惧记忆。

理论规定，记忆是在皮质投射神经元网络中编码的。相反，GABA 能中间神经元被认为主要起到抑制投射神经元的作用，从而施加网络增益控制，这是一个重要但纯粹的调节作用。在这里，我们在雄性小鼠身上展示了联想恐惧学习增强了内侧前额叶生长抑素 (SST) 中间神经元的突触传递和线索特异性活动，并且这些细胞的激活控制了记忆编码和表达。此外，SST 和小白蛋白中间神经元的突触组织为 SST 中间神经元诱发的内侧前额叶皮层输出神经元的去抑制和与防御行为相关的远程大脑区域的募集提供了潜在的回路基础。这些数据表明，

更新日期：2019-12-17

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