Diabetes, a metabolic syndrome of global importance has been on a progressive rise in recent years. Several pharmacological approaches have been made, which have proved effective, but with underlying side effects. Bioactive hydrolysates (BHs) and peptides (BPs) from food sources, however, have shown the relative advantage of imparting less adverse effects. Furthermore, BHs and BPs from food have been discovered to impart their antidiabetic potentials through one or more mechanisms such as inhibition of digestive enzymes, inhibition of the antigenic enzyme - Dipeptyl peptidase IV (DPP-IV), decrease in blood glucose levels and increase in insulin uptake. Several plants and animal sources have been used as protein sources for the isolation of antidiabetic hydrolysates and peptides through different mechanisms and analytical techniques. This review integrates recent research information about several popular and unconventional food sources of BHs and BPs, their isolation techniques, antidiabetic effects and protein profiles. In addition, the fractionation technique(s) employed in each study and inhibition potentials of BHs and BPs are reviewed. This article is intended to supplement accessible scholarly literature and intellectual awareness on the subject of food-oriented approach for the management of diabetes.

中文翻译：

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最近从多种食物来源中分离出的抗糖尿病水解物和多肽：综述。

糖尿病是一种具有全球重要性的代谢综合症，近年来一直在逐步上升。已经采取了几种药理学方法，这些方法已被证明是有效的，但具有潜在的副作用。然而，来自食物来源的生物活性水解物（BHs）和肽（BPs）已显示出带来较少不良影响的相对优势。此外，已发现食物中的BH和BP可通过一种或多种机制（例如，抑制消化酶，抑制抗原性酶-二肽基肽酶IV（DPP-IV），降低血糖水平和增加血糖）来发挥其抗糖尿病的潜能。胰岛素摄取。几种动植物来源已被用作蛋白质来源，可通过不同的机理和分析技术来分离抗糖尿病的水解产物和多肽。这篇综述综合了有关BHs和BPs几种流行和非常规食物来源，其分离技术，抗糖尿病作用和蛋白质谱的最新研究信息。此外，还对每项研究中使用的分级分离技术以及BHs和BPs的抑制潜力进行了综述。本文旨在补充有关以食物为导向的糖尿病治疗方法的学术文献和知识意识。