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Superior temperature sensing of small-sized upconversion nanocrystals for simultaneous bioimaging and enhanced synergetic therapy.
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 4.2 ) Pub Date : 2019-12-14 , DOI: 10.1016/j.nano.2019.102135 Guofeng Liu 1 , Fan Jiang 2 , Yeqing Chen 3 , Chang Yu 2 , Binbin Ding 2 , Shuai Shao 2 , Mochen Jia 4 , Ping'an Ma 2 , Zuoling Fu 4 , Jun Lin 2
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 4.2 ) Pub Date : 2019-12-14 , DOI: 10.1016/j.nano.2019.102135 Guofeng Liu 1 , Fan Jiang 2 , Yeqing Chen 3 , Chang Yu 2 , Binbin Ding 2 , Shuai Shao 2 , Mochen Jia 4 , Ping'an Ma 2 , Zuoling Fu 4 , Jun Lin 2
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The upconversion nanoparticles (UCNPs) exhibit versatility applications aiming at biological domains for decades on account of superior optical characteristics. Nevertheless, the UCNPs are confronted with tremendous difficulties in biological field owing to large grain size, low fluorescence efficiency, and single function. Herein, the small-sized CaF2: Yb3+/Er3+ UCNPs coated with NaGdF4 shells (activator and inert, UCNPs-RBHA-Pt-PEG) not only burst out strong fluorescence, but also provide prominent diagnosability by taking advantage of magnetic resonance (MR) imaging as well as temperature sensing and inhibiting capability for CT26 tumor tissues based on synergetic therapy modality of photodynamic therapy (PDT) and chemotherapy. Ultimately, the tumor sizes decrease visibly after injected with UCNPs-RBHA-Pt-PEG and simultaneously irradiated with near infrared (NIR) light at low power density (0.35 W/cm2, 6 min). In summary, the small-sized and strong-fluorescent single nanoparticles with multi-functions may provide a valuable enlightenment for diagnosis and treatment of cancer in the future.
中文翻译：
小型上转换纳米晶体具有出色的温度感测功能，可同时进行生物成像和增强的协同治疗。
由于优异的光学特性，上转换纳米粒子（UCNPs）展示了针对生物学领域的多功能性应用数十年。然而，由于大粒径，低荧光效率和单一功能，UCNP在生物领域面临巨大的困难。在此，涂有NaGdF4壳（活化剂和惰性物质，UCNPs-RBHA-Pt-PEG）的小型CaF2：Yb3 + / Er3 + UCNPs不仅发出强烈的荧光，而且还利用磁共振（MR）提供了出色的可诊断性基于光动力疗法（PDT）和化学疗法的协同治疗方式对CT26肿瘤组织的成像以及温度感测和抑制能力。最终，注射UCNPs-RBHA-Pt-PEG并同时以低功率密度（0.35 W / cm2，6分钟）照射近红外（NIR）光后，肿瘤大小明显减小。综上所述，具有多功能的小尺寸，强荧光的单个纳米颗粒可能为将来的癌症诊断和治疗提供有价值的启示。
更新日期：2019-12-17
中文翻译：
小型上转换纳米晶体具有出色的温度感测功能，可同时进行生物成像和增强的协同治疗。
由于优异的光学特性，上转换纳米粒子（UCNPs）展示了针对生物学领域的多功能性应用数十年。然而，由于大粒径，低荧光效率和单一功能，UCNP在生物领域面临巨大的困难。在此，涂有NaGdF4壳（活化剂和惰性物质，UCNPs-RBHA-Pt-PEG）的小型CaF2：Yb3 + / Er3 + UCNPs不仅发出强烈的荧光，而且还利用磁共振（MR）提供了出色的可诊断性基于光动力疗法（PDT）和化学疗法的协同治疗方式对CT26肿瘤组织的成像以及温度感测和抑制能力。最终，注射UCNPs-RBHA-Pt-PEG并同时以低功率密度（0.35 W / cm2，6分钟）照射近红外（NIR）光后，肿瘤大小明显减小。综上所述，具有多功能的小尺寸，强荧光的单个纳米颗粒可能为将来的癌症诊断和治疗提供有价值的启示。
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