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Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy.
Neurobiology of Disease ( IF 5.1 ) Pub Date : 2019-12-14 , DOI: 10.1016/j.nbd.2019.104715 Li-Tao Yi 1 , Shu-Qi Dong 2 , Shuang-Shuang Wang 2 , Min Chen 2 , Cheng-Fu Li 3 , Di Geng 1 , Ji-Xiao Zhu 4 , Qing Liu 1 , Jie Cheng 1
Neurobiology of Disease ( IF 5.1 ) Pub Date : 2019-12-14 , DOI: 10.1016/j.nbd.2019.104715 Li-Tao Yi 1 , Shu-Qi Dong 2 , Shuang-Shuang Wang 2 , Min Chen 2 , Cheng-Fu Li 3 , Di Geng 1 , Ji-Xiao Zhu 4 , Qing Liu 1 , Jie Cheng 1
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Cisplatin, a commonly used chemotherapy drug, can increase the survival rate of cancer patients. However, it often causes various side effects, including neuronal deficit-induced cognitive impairment. Considering that curcumin is effective in neuronal protection, the action of curcumin on cognitive improvement was evaluated in cisplatin-treated C57BL/6 mice in the present study. Our results first showed that curcumin restored impaired cognitive behaviors. Consistent with this, neurogenesis and synaptogenesis were improved by curcumin. In addition, cisplatin-induced dysfunction of apoptosis-related proteins was partly reversed by curcumin. Moreover, cisplatin-induced autophagy was enhanced by curcumin. Our results also indicated that cisplatin induced autophagy through the endoplasmic reticulum (ER) stress-mediated ATF4-Akt-mTOR signaling pathway. Curcumin activated AMPK-JNK signaling, which mediated both mTOR inhibition and Bcl-2 upregulation and in turn enhanced autophagy and suppressed apoptosis, respectively. In contrast, pretreatment with the autophagy inhibitor 3-methyladenine (3-MA) completely abolished the effects of curcumin on cognitive improvement and improved neurogenesis, synaptogenesis and autophagy. Our results show that cognitive improvement induced by curcumin during chemotherapy is mediated by the enhancement of hippocampal autophagy.
中文翻译：
姜黄素通过增强化疗中的自噬来减轻认知障碍。
顺铂是常用的化疗药物，可以提高癌症患者的生存率。然而，它经常引起各种副作用，包括神经元缺陷引起的认知障碍。考虑到姜黄素对神经元保护有效，本研究在顺铂治疗的 C57BL/6 小鼠中评估了姜黄素对认知改善的作用。我们的结果首先表明姜黄素可以恢复受损的认知行为。与此一致的是，姜黄素改善了神经发生和突触发生。此外，顺铂诱导的凋亡相关蛋白功能障碍可被姜黄素部分逆转。此外，姜黄素增强了顺铂诱导的自噬。我们的结果还表明顺铂通过内质网（ER）应激介导的 ATF4-Akt-mTOR 信号通路诱导自噬。姜黄素激活 AMPK-JNK 信号传导，介导 mTOR 抑制和 Bcl-2 上调，进而分别增强自噬和抑制细胞凋亡。相比之下，用自噬抑制剂 3-甲基腺嘌呤 (3-MA) 进行预处理完全消除了姜黄素对认知改善的作用，并改善了神经发生、突触发生和自噬。我们的结果表明，化疗期间姜黄素诱导的认知改善是通过增强海马自噬介导的。
更新日期：2019-12-17
中文翻译：
姜黄素通过增强化疗中的自噬来减轻认知障碍。
顺铂是常用的化疗药物，可以提高癌症患者的生存率。然而，它经常引起各种副作用，包括神经元缺陷引起的认知障碍。考虑到姜黄素对神经元保护有效，本研究在顺铂治疗的 C57BL/6 小鼠中评估了姜黄素对认知改善的作用。我们的结果首先表明姜黄素可以恢复受损的认知行为。与此一致的是，姜黄素改善了神经发生和突触发生。此外，顺铂诱导的凋亡相关蛋白功能障碍可被姜黄素部分逆转。此外，姜黄素增强了顺铂诱导的自噬。我们的结果还表明顺铂通过内质网（ER）应激介导的 ATF4-Akt-mTOR 信号通路诱导自噬。姜黄素激活 AMPK-JNK 信号传导，介导 mTOR 抑制和 Bcl-2 上调，进而分别增强自噬和抑制细胞凋亡。相比之下，用自噬抑制剂 3-甲基腺嘌呤 (3-MA) 进行预处理完全消除了姜黄素对认知改善的作用，并改善了神经发生、突触发生和自噬。我们的结果表明，化疗期间姜黄素诱导的认知改善是通过增强海马自噬介导的。
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