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Effects of fine particulate matter (PM2.5) on ovarian function and embryo quality in mice.
Environment International ( IF 10.3 ) Pub Date : 2019-12-13 , DOI: 10.1016/j.envint.2019.105338
Bao-Qiong Liao 1 , Chao-Bin Liu 2 , Shu-Juan Xie 3 , Yu Liu 4 , Ya-Bin Deng 5 , Shu-Wen He 6 , Xian-Pei Fu 6 , Bin-Bin Fu 6 , Ya-Long Wang 6 , Ming-Huang Chen 6 , Yan-Hong Lin 6 , Fei-Ping Li 6 , Xi Xie 2 , Xin-Ru Hong 7 , Hai-Long Wang 8
Affiliation  

Fine particulate matter (PM2.5) has an adverse effect on reproductive function, in particular causing reduced male reproductive function, but relatively few studies have directly targeted its effects on female reproduction. To investigate the effects of PM2.5 exposure on female reproduction, we exposed female mice to PM2.5 by intratracheal instillation for 28 days, and evaluated apoptosis of ovarian granulosa cells and oocytes and the quality embryos after insemination. Our results showed increased numbers of apoptotic granulosa cells and oocytes after exposure to elevated concentrations of PM2.5, which had adverse effects on female fertility via compromising embryo development and quality. We conclude that PM2.5 induced apoptosis of ovarian granulosa cells and oocytes leading to disrupted embryo development and female fertility in mice.

中文翻译:

细颗粒物(PM2.5)对小鼠卵巢功能和胚胎质量的影响。

细颗粒物(PM2.5)对生殖功能有不利影响,特别是引起男性生殖功能降低,但相对较少的研究直接针对其对女性生殖的影响。为了研究PM2.5暴露对雌性生殖的影响,我们通过气管内滴注使雌性小鼠暴露于PM2.5 28天,并评估了授精后卵巢颗粒细胞和卵母细胞的凋亡以及优质胚胎。我们的结果表明,暴露于高浓度的PM2.5后,凋亡性颗粒细胞和卵母细胞的数量增加,这通过损害胚胎发育和质量而对女性生育力产生不利影响。我们得出的结论是,PM2.5诱导卵巢颗粒细胞和卵母细胞凋亡,从而导致小鼠胚胎发育和雌性生育力受到破坏。
更新日期:2019-12-17
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