Health risk behaviours (HRB) across the lifespan have been associated with higher cumulative physiological burden as measured by allostatic load (AL). This study examines the contribution of HRB and their effects on multisystem biological risk associated with morbidity and early mortality. We systematically reviewed the literature to assess the links between HRB and AL. Twenty-six eligible human studies were included in our assessment of the current literature investigating the association of different HRB that included overeating/obesity, alcohol, smoking, drug use, physical inactivity and sleep impairments in relation to AL. We found that 50 % of obesity and substance abuse, 75 % of sleep and 62.5 % of combined HRB studies showed a significant association with AL. Lifestyle coping behaviours therefore have a significant contribution to AL. This study is among the first to explore multiple domains of HRB in relation to AL. Further research should focus on evaluating lifestyle factors that adapt HRB as a strategy to cope with chronic stress to help decrease AL and resulting long-term negative health consequences.

中文翻译：

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健康风险行为和同素负荷：系统评价。

整个生命周期内的健康风险行为（HRB）与更高的累积生理负担相关联，这是通过恒静负荷（AL）衡量的。这项研究检查了HRB的贡献及其对与发病率和早期死亡率相关的多系统生物学风险的影响。我们系统地回顾了文献，以评估HRB和AL之间的联系。在我们评估不同HRB关联的当前文献评估中，包括26项符合条件的人体研究，其中包括与AL相关的暴饮暴食/肥胖，酗酒，吸烟，吸毒，缺乏运动和睡眠障碍。我们发现50％的肥胖和药物滥用，75％的睡眠和62.5％的HRB联合研究显示与AL有显着相关性。因此，生活方式应对行为对AL有重要贡献。这项研究是最早探索与AL相关的HRB多个领域的研究之一。进一步的研究应集中于评估适应HRB的生活方式因素，以此作为应对慢性压力的策略，以帮助降低AL和由此带来的长期负面健康后果。