Neuromodulation techniques have shown promising efficacy on memory function and understanding the epigenetic mechanisms contributing to these processes would shed light on the molecular outcomes essential for cognition. In this review, we highlight some epigenetic mechanisms underlying neuromodulation and regulatory effects of neuronal activity-induced DNA methylation on genes that are highly involved in memory formation. Next, we examine the evidence to support DNA methyltransferase 3a, methyl-CpG binding protein 2, and DNA demethylase as possible memory modulation targets. Finally, we report the recent developments in the field of neuromodulation and explore the potential of these techniques for future neuroepigenetic research.

中文翻译：

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记忆和神经调节：DNA甲基化的观点。

神经调节技术已显示出对记忆功能有希望的功效，了解有助于这些过程的表观遗传机制将阐明认知必不可少的分子结果。在这篇综述中，我们着重介绍了一些表观遗传机制，这些机制涉及神经调节和神经元活动诱导的DNA甲基化对高度参与记忆形成的基因的调节作用。接下来，我们检查支持DNA甲基转移酶3a，甲基CpG结合蛋白2和DNA脱甲基酶作为可能的记忆调节靶点的证据。最后，我们报告了神经调节领域的最新进展，并探讨了这些技术在未来神经表观遗传学研究中的潜力。