Universal antibiotic tolerance arising from antibiotic-triggered accumulation of pyocyanin in Pseudomonas aeruginosa.,PLOS Biology

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Universal antibiotic tolerance arising from antibiotic-triggered accumulation of pyocyanin in Pseudomonas aeruginosa.
PLOS Biology ( IF 7.8 ) Pub Date : 2019-12-16 , DOI: 10.1371/journal.pbio.3000573
Kui Zhu ₁ , Shang Chen ₁ , Tatyana A Sysoeva ₂ , Lingchong You _{2,

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Affiliation

Pseudomonas aeruginosa is an opportunistic pathogen that often infects open wounds or patients with cystic fibrosis. Once established, P. aeruginosa infections are notoriously difficult to eradicate. This difficulty is in part due to the ability of P. aeruginosa to tolerate antibiotic treatment at the individual-cell level or through collective behaviors. Here, we describe a new phenomenon by which P. aeruginosa tolerates antibiotic treatment. In particular, treatment of P. aeruginosa with sublethal concentrations of antibiotics covering all major classes promoted accumulation of the redox-sensitive phenazine pyocyanin (PYO). PYO in turn conferred general tolerance against diverse antibiotics for both P. aeruginosa and other gram-negative and gram-positive bacteria. This property is shared by other redox-active phenazines produced by P. aeruginosa. Our discovery sheds new insights into the physiological functions of phenazines and has implications for designing effective antibiotic treatment protocols.

中文翻译：

抗生素引发的铜绿假单胞菌中绿脓素积累引起的普遍抗生素耐受性。

铜绿假单胞菌是一种机会性病原体，经常感染开放性伤口或囊性纤维化患者。一旦形成，铜绿假单胞菌感染就很难根除。这种困难部分是由于铜绿假单胞菌能够在个体细胞水平或通过集体行为耐受抗生素治疗。在这里，我们描述了铜绿假单胞菌耐受抗生素治疗的新现象。特别是，用亚致死浓度的涵盖所有主要类别的抗生素治疗铜绿假单胞菌，促进了氧化还原敏感的吩嗪绿脓菌素（PYO）的积累。 PYO 反过来赋予铜绿假单胞菌和其他革兰氏阴性和革兰氏阳性细菌对多种抗生素的普遍耐受性。铜绿假单胞菌产生的其他氧化还原活性吩嗪也具有这种特性。我们的发现为吩嗪的生理功能提供了新的见解，并对设计有效的抗生素治疗方案具有重要意义。

更新日期：2019-12-17

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