BACKGROUND In postmenopausal women with established cardiovascular disease (CVD), it is unknown whether a history of pregnancy complications are related to multisite artery disease (MSAD), defined as atherosclerotic lesions in at least two major vascular beds. Pregnancy complications are an established risk factor for CVD. This study aimed to investigate the frequency of pregnancy complications and their association to specific atherosclerotic manifestations and prediction of MSAD in older women with and without CVD. METHODS In total, 556 women were invited to participate in the study. Of these women 307 reported former pregnancy from a cohort of women with (n = 233) and without CVD (n = 74). The self-reported frequency of pregnancy complications were surveyed retrospectively by a questionnaire that included miscarriage, subfertility, gestational hypertension (GHT) and/or preeclampsia (PE), low birth weight, preterm birth, bleeding in late pregnancy, gestational diabetes mellitus and high birth weight. Three vascular beds were examined, the peripheral, carotid and coronary arteries. RESULTS The mean age was 67.5 (SD 9.5) years. GHT and/or PE tended to be more common, but not significant, in women with CVD than in women without (20.3% vs 10.8%, p = 0.066). Among women with GHT and/or PE, hypertension later in life were more frequent than in women without (66.7% vs 47.4%, p = 0.010). GHT and/or PE were not associated with specific atherosclerotic manifestations or prediction of MSAD. CONCLUSIONS In older women with established CVD, pregnancy complications was not associated to specific atherosclerotic manifestations and may not provide additional value to the risk evaluation for MSAD.

中文翻译：

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自我报告的妊娠并发症会增加患有心血管疾病的老年妇女的风险评估吗？

背景技术在患有已确定的心血管疾病（CVD）的绝经后妇女中，怀孕并发症的病史是否与多部位动脉疾病（MSAD）有关，MSAD被定义为至少两个主要血管床中的动脉粥样硬化病变，这一点尚不清楚。怀孕并发症是确定的CVD危险因素。这项研究的目的是调查患有和不患有CVD的老年妇女妊娠并发症的发生频率及其与特定动脉粥样硬化表现的关联以及MSAD的预测。方法总共邀请了556名妇女参加该研究。在这些妇女中，有307名报告了一群（n = 233）和没有CVD（n = 74）的妇女以前的怀孕情况。自我报告的妊娠并发症发生率通过包括流产，不育，妊娠高血压（GHT）和/或先兆子痫（PE），低出生体重，早产，妊娠晚期出血，妊娠糖尿病和高出生体重。检查了三张血管床，外周血管，颈动脉和冠状动脉。结果平均年龄为67.5（SD 9.5）岁。患有CVD的妇女比没有CVD的妇女更倾向于GHT和/或PE（20.3％vs 10.8％，p = 0.066）。在患有GHT和/或PE的女性中，晚年以后的高血压患者比没有肥胖的女性更为频繁（66.7％vs 47.4％，p = 0.010）。GHT和/或PE与特定的动脉粥样硬化表现或MSAD的预测无关。结论在已建立CVD的老年妇女中，