BACKGROUND To investigate whether there are bi-directional associations between anxiety and mood disorders and body mass index (BMI) in a cohort of young adults. METHODS We analysed data from the 2004-2006 (baseline) and 2009-2011 (follow-up) waves of the Childhood Determinants of Adult Health study. Lifetime DSM-IV anxiety and mood disorders were retrospectively diagnosed with the Composite International Diagnostic Interview. Potential mediators were individually added to the base models to assess their potential role as a mediator of the associations. RESULTS In males, presence of mood disorder history at baseline was positively associated with BMI gain (β = 0.77, 95% CI: 0.14-1.40), but baseline BMI was not associated with subsequent risk of mood disorder. Further adjustment for covariates, including dietary pattern, physical activity, and smoking reduced the coefficient (β) to 0.70 (95% CI: 0.01-1.39), suggesting that the increase in BMI was partly mediated by these factors. In females, presence of mood disorder history at baseline was not associated with subsequent weight gain, however, BMI at baseline was associated with higher risk of episode of mood disorder (RR per kg/m2: 1.04, 95% CI: 1.01-1.08), which was strengthened (RR per kg/m2 = 1.07, 95% CI: 1.00-1.15) after additional adjustment in the full model. There was no significant association between anxiety and change in BMI and vice-versa. CONCLUSION The results do not suggest bidirectional associations between anxiety and mood disorders, and change in BMI. Interventions promoting healthy lifestyle could contribute to reducing increase in BMI associated with mood disorder in males, and excess risk of mood disorder associated with BMI in females.

中文翻译：

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年轻人抑郁，焦虑和体重变化之间的关联。

背景技术为了研究在一群年轻人中焦虑和情绪障碍与体重指数（BMI）之间是否存在双向关联。方法我们分析了2004-2006年（基线）和2009-2011年（后续）成人健康儿童决定因素研究的数据。生命综合DSM-IV焦虑和情绪障碍通过《综合国际诊断访谈》进行了回顾性诊断。将潜在的调解人分别添加到基本模型中，以评估其作为协会调解人的潜在作用。结果在男性中，基线时的情绪障碍史与BMI增加呈正相关（β= 0.77，95％CI：0.14-1.40），但基线BMI与随后的情绪障碍风险无关。对协变量进行进一步调整，包括饮食习惯，体育锻炼，吸烟使系数（β）降低至0.70（95％CI：0.01-1.39），表明BMI的升高部分是由这些因素介导的。在女性中，基线时是否存在情绪障碍史与随后的体重增加无关，但是，基线时的BMI与情绪障碍发作的较高风险相关（RR / kg / m2：1.04，95％CI：1.01-1.08） ，在完整模型中进行了其他调整后，其强度得到了增强（每公斤/平方米的RR = 1.07，95％CI：1.00-1.15）。焦虑与体重指数变化之间无显着相关性，反之亦然。结论结果并不表明焦虑和情绪障碍与BMI的变化之间存在双向关联。促进健康生活方式的干预措施可能有助于减少男性与情绪障碍相关的BMI升高，