当前位置：
X-MOL 学术
›
BMC Pediatr.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Prognostic value of perioperative NT-proBNP after corrective surgery for pediatric congenital heart defects.
BMC Pediatrics ( IF 2.0 ) Pub Date : 2019-12-16 , DOI: 10.1186/s12887-019-1830-y Fangqin Lin 1 , Lingling Zheng 1 , Yanqin Cui 2 , Weidan Chen 2 , Ramit Kumar Gupta 2 , Huixian Li 1 , Xinxin Chen 2 , Huimin Xia 3 , Huiying Liang 1
BMC Pediatrics ( IF 2.0 ) Pub Date : 2019-12-16 , DOI: 10.1186/s12887-019-1830-y Fangqin Lin 1 , Lingling Zheng 1 , Yanqin Cui 2 , Weidan Chen 2 , Ramit Kumar Gupta 2 , Huixian Li 1 , Xinxin Chen 2 , Huimin Xia 3 , Huiying Liang 1
Affiliation
BACKGROUND
It is critically important to assess the prognostic value of NT-proBNP in the form of repeated measures among children undergoing surgery for congenital heart defects (CHD). The aim of the present study is to assess the value of repeated perioperative NT-proBNP in evaluating the time dependent and temporal trajectory in prognostics diagnosis during the perioperative period in a large series of children with CHD.
METHODS
Repeated measures of NT-proBNP from 329 consecutive children with CHD were obtained before and 1, 12, and 36 h after surgery, respectively. For fully utilizing longitudinal characteristics, we employed parallel cross-sectional logistic regression, a two stage mixed effect model and trajectories over time analysis to mine the predictive value of perioperative NT-proBNP on the binary outcome of prolonged intensive care unit (ICU) stay.
RESULTS
The two stage mixed effects model confirmed that both the mean NT-proBNP level (aOR = 1.46, P = 0.001) and the time trends had prognostic value on the prediction of prolonged ICU stay. In the fully adjusted logistic regression analyses based on gaussian distributions, "rapidly rising NT-proBNP" put the subjects at 5.4-times higher risk of prolonged ICU stay compared with "slowly rising" group (aOR = 5.40, P = 0.003).
CONCLUSIONS
Comprehensive assessment of the time dependent and temporal trajectory in perioperative NT-proBNP, indicated by repeated measurements, can provide more accurate identification of children with higher risk of prolonged ICU stay after CHD surgery.
中文翻译：
围手术期NT-proBNP矫正手术对小儿先天性心脏缺损的预后价值。
背景技术以反复测量的形式评估先天性心脏缺陷（CHD）手术患儿的NT-proBNP的预后价值至关重要。本研究的目的是评估围手术期反复进行的NT-proBNP在评估一系列冠心病儿童围手术期预后诊断中的时间依赖性和时间轨迹的价值。方法分别在手术前，手术后1、12和36 h对329例CHD患儿进行NT-proBNP的重复测定。为了充分利用纵向特征，我们采用了平行截面逻辑回归，一个两阶段混合效应模型和随时间变化的轨迹分析，以挖掘围手术期NT-proBNP对重症监护病房（ICU）长期住院的二元结局的预测价值。结果两阶段混合效应模型证实平均NT-proBNP水平（aOR = 1.46，P = 0.001）和时间趋势对预测ICU长期停留具有预后价值。在基于高斯分布的完全调整的logistic回归分析中，与“缓慢上升”组相比，“迅速上升NT-proBNP”使受试者长期ICU停留的风险高5.4倍（aOR = 5.40，P = 0.003）。结论对围手术期NT-proBNP的时间依赖性和时间轨迹进行了综合评估，通过反复测量表明，
更新日期：2019-12-16
中文翻译：
围手术期NT-proBNP矫正手术对小儿先天性心脏缺损的预后价值。
背景技术以反复测量的形式评估先天性心脏缺陷（CHD）手术患儿的NT-proBNP的预后价值至关重要。本研究的目的是评估围手术期反复进行的NT-proBNP在评估一系列冠心病儿童围手术期预后诊断中的时间依赖性和时间轨迹的价值。方法分别在手术前，手术后1、12和36 h对329例CHD患儿进行NT-proBNP的重复测定。为了充分利用纵向特征，我们采用了平行截面逻辑回归，一个两阶段混合效应模型和随时间变化的轨迹分析，以挖掘围手术期NT-proBNP对重症监护病房（ICU）长期住院的二元结局的预测价值。结果两阶段混合效应模型证实平均NT-proBNP水平（aOR = 1.46，P = 0.001）和时间趋势对预测ICU长期停留具有预后价值。在基于高斯分布的完全调整的logistic回归分析中，与“缓慢上升”组相比，“迅速上升NT-proBNP”使受试者长期ICU停留的风险高5.4倍（aOR = 5.40，P = 0.003）。结论对围手术期NT-proBNP的时间依赖性和时间轨迹进行了综合评估，通过反复测量表明，
京公网安备 11010802027423号