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Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2020-01-16 , DOI: 10.1021/acsanm.9b01959 N.S.K. Gowthaman 1 , Hong Ngee Lim 1, 2 , Sekar Shankar 3
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2020-01-16 , DOI: 10.1021/acsanm.9b01959 N.S.K. Gowthaman 1 , Hong Ngee Lim 1, 2 , Sekar Shankar 3
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Herein, we present the electrochemical scaffold for the quantification of acetaminophen (ACAP) using a silver phosphate nanoparticle (Ag–P NP) fabricated screen-printed carbon electrode (SPCE). The Ag–P NPs were synthesized by a facile method through simply refluxing the reaction mixture of AgNO3 and Na2HPO4 at 120 °C in the presence of citric acid followed by calcination. The obtained Ag–P NPs were characterized by Fourier transform infrared (FT-IR) and UV–vis diffused reflectance spectroscopies, X-ray diffraction (XRD), and electron microscopic tools. The as-prepared Ag–P NPs exhibited the bandgap energy of 2.2 eV, and the prepared Ag–P NPs have a sphere-like morphology with 13 nm average size. The main strategy of this study lies in providing the electrocatalytic oxidation of ACAP at the surface of the Ag–P NPs modified electrode. The developed sensor was applied to determine ACAP from commercial drugs and human fluids. The Ag-P NPs modified electrode detects ACAP in the linear concentration of 0.1–1900 μM with the lowest detection limit of 0.39 nM (S/N = 3) with the superior sensitivity of 2244.4 μA/μM·cm2. Further, the developed sensor showed excellent specificity, sensitivity, reproducibility, and stability compared to the previously reported sensors. Finally, the developed sensor has been exploited to testify the practicability by determining the concentration of ACAP from pharmaceutical samples and human fluids. The synthesized Ag–P NPs were also utilized for antibacterial studies against Staphylococcus aureus and Aspergillus niger.
中文翻译：
基于磷酸银纳米粒子的电化学支架，用于定量体液和药物制剂中的对乙酰氨基酚
在这里，我们介绍了使用磷酸银纳米颗粒（Ag-P NP）制成的丝网印刷碳电极（SPCE）定量对乙酰氨基酚（ACAP）的电化学支架。通过简单地回流AgNO 3和Na 2 HPO 4的反应混合物，通过简便的方法合成了Ag-P NP。在柠檬酸存在下于120°C进行煅烧。通过傅立叶变换红外（FT-IR）和紫外可见漫反射光谱，X射线衍射（XRD）和电子显微镜工具对获得的Ag-P NP进行表征。制备的Ag-P NPs的带隙能为2.2 eV，制备的Ag-P NPs的球形结构平均尺寸为13 nm。这项研究的主要策略在于在Ag-P NPs修饰电极的表面提供ACAP的电催化氧化。研发的传感器用于确定商业药物和人体液体中的ACAP。Ag-P NPs修饰电极可检测线性浓度为0.1–1900μM的ACAP，最低检测限为0.39 nM（S / N= 3），灵敏度高达2244.4μA/μM·cm 2。此外，与以前报道的传感器相比，开发的传感器显示出优异的特异性，灵敏度，可重复性和稳定性。最后，已开发的传感器已被用于通过确定药物样品和人体液中ACAP的浓度来证明其实用性。合成的Ag-P NP也用于金黄色葡萄球菌和黑曲霉的抗菌研究。
更新日期：2020-01-17
中文翻译：
基于磷酸银纳米粒子的电化学支架，用于定量体液和药物制剂中的对乙酰氨基酚
在这里，我们介绍了使用磷酸银纳米颗粒（Ag-P NP）制成的丝网印刷碳电极（SPCE）定量对乙酰氨基酚（ACAP）的电化学支架。通过简单地回流AgNO 3和Na 2 HPO 4的反应混合物，通过简便的方法合成了Ag-P NP。在柠檬酸存在下于120°C进行煅烧。通过傅立叶变换红外（FT-IR）和紫外可见漫反射光谱，X射线衍射（XRD）和电子显微镜工具对获得的Ag-P NP进行表征。制备的Ag-P NPs的带隙能为2.2 eV，制备的Ag-P NPs的球形结构平均尺寸为13 nm。这项研究的主要策略在于在Ag-P NPs修饰电极的表面提供ACAP的电催化氧化。研发的传感器用于确定商业药物和人体液体中的ACAP。Ag-P NPs修饰电极可检测线性浓度为0.1–1900μM的ACAP，最低检测限为0.39 nM（S / N= 3），灵敏度高达2244.4μA/μM·cm 2。此外，与以前报道的传感器相比，开发的传感器显示出优异的特异性，灵敏度，可重复性和稳定性。最后，已开发的传感器已被用于通过确定药物样品和人体液中ACAP的浓度来证明其实用性。合成的Ag-P NP也用于金黄色葡萄球菌和黑曲霉的抗菌研究。
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