Cascaded Multiresponsive Self-Assembled 19F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification.,Nano Letters

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Cascaded Multiresponsive Self-Assembled 19F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification.
Nano Letters ( IF 9.6 ) Pub Date : 2019-12-16 , DOI: 10.1021/acs.nanolett.9b04016
Xiaoxue Tang ₁ , Xuanqing Gong ₁ , Ao Li ₁ , Hongyu Lin ₁ , Chenyu Peng ₂ , Xianzhong Zhang ₂ , Xiaoyuan Chen ₃ , Jinhao Gao ₁

Affiliation

Molecular probes featuring promising capabilities including specific targeting, high signal-to-noise ratio, and in situ visualization of deep tissues are in great demand for tumor diagnosis and therapy. 19F magnetic resonance imaging (MRI) techniques incorporating stimuli-responsive probes are anticipated to be highly beneficial for specific detection and imaging of tumors because of negligible background and deep tissue penetration. Herein, we report a cascaded multiresponsive self-assembled nanoprobe, which enables sequential redox-triggered and near-infrared (NIR) irradiation-induced 19F MR signal activation/amplification for sensing and imaging. Specifically, we designed and synthesized a cascaded multiresponsive 19F-bearing nanoprobe based on the self-assembly of amphiphilic redox-responsive 19F-containing polymers and NIR-absorbing indocyanine green (ICG) molecules. It could realize the activation of 19F signals in the reducing tumor microenvironment and subsequent signal amplification via the photothermal process. This stepwise two-stage activation/amplification of 19F signals was validated by 19F NMR and MRI both in vitro and in vivo. The multiresponsive 19F nanoprobes capable of cascaded 19F signal activation/amplification and photothermal effect exertion can provide accurate sensing and imaging of tumors.

中文翻译：

级联的多响应自组装19F MRI纳米探针，具有氧化还原触发激活和NIR诱导的扩增作用。

对肿瘤的诊断和治疗有巨大需求的分子探针具有广阔的前景，包括特异性靶向，高信噪比和深层组织的原位可视化。由于忽略了背景和深层组织穿透，结合刺激响应探针的19F磁共振成像（MRI）技术预计对肿瘤的特异性检测和成像非常有利。在本文中，我们报告了级联的多响应自组装纳米探针，该探针能够依次进行氧化还原触发和近红外（NIR）辐射诱导的19F MR信号激活/放大，以进行传感和成像。具体来说，我们基于两亲性含氧化还原反应性19F的聚合物和吸收NIR的吲哚菁绿（ICG）分子的自组装，设计并合成了一个级联的多反应性含19F纳米探针。它可以在还原性肿瘤微环境中实现19F信号的激活，并通过光热过程实现随后的信号放大。在体外和体内通过19F NMR和MRI验证了19F信号的这种逐步的两阶段激活/扩增。能够级联19F信号激活/放大和光热效应发挥作用的多响应19F纳米探针可以提供对肿瘤的精确感测和成像。在体外和体内通过19F NMR和MRI验证了19F信号的这种逐步的两阶段激活/扩增。能够级联19F信号激活/放大和光热效应发挥作用的多响应19F纳米探针可以提供对肿瘤的精确感测和成像。在体外和体内通过19F NMR和MRI验证了19F信号的这种逐步的两阶段激活/扩增。能够级联19F信号激活/放大和光热效应发挥作用的多响应19F纳米探针可以提供对肿瘤的精确感测和成像。

更新日期：2019-12-19

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