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Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p.
Cell Death & Disease ( IF 8.1 ) Pub Date : 2019-12-16 , DOI: 10.1038/s41419-019-2180-2 Xiaoping Li 1 , Bo Yang 1 , Haixia Ren 2 , Ting Xiao 3 , Liang Zhang 1 , Lei Li 1 , Mingjiang Li 1 , Xuhui Wang 1 , Honggang Zhou 4 , Weidong Zhang 1
Cell Death & Disease ( IF 8.1 ) Pub Date : 2019-12-16 , DOI: 10.1038/s41419-019-2180-2 Xiaoping Li 1 , Bo Yang 1 , Haixia Ren 2 , Ting Xiao 3 , Liang Zhang 1 , Lei Li 1 , Mingjiang Li 1 , Xuhui Wang 1 , Honggang Zhou 4 , Weidong Zhang 1
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In this study, we identified a novel circRNA, circ_0002483, and further investigated its functions in the progression and Taxol resistance of NSCLC. We found that circ_0002483 was expressed at low levels in NSCLC tissues and cell lines. Functional assays indicated that circ_0002483 overexpression significantly inhibited NSCLC cell proliferation and invasion in vitro and in vivo and enhanced the sensitivity of NSCLC cells to Taxol. Mechanistically, circ_0002483 was identified to sponge multiple miRNAs including miR-182-5p (also named miR-182), miR-520q-3p, miR-582-3p, miR-587, and miR-655. In addition, circ_0002483 was also demonstrated to regulate the expression of GRB2, FOXO1, and FOXO3, three target genes of miR-182-5p, by sponging miR-182-5p. Circ_0002483 was demonstrated to inhibit NSCLC progression in vitro and in vivo and enhanced the sensitivity of NSCLC cells to Taxol by sponging miR-182-5p to release the inhibition on GRB2, FOXO1, and FOXO3 mRNAs.
中文翻译：
Hsa_circ_0002483通过靶向miR-182-5p抑制非小细胞肺癌的进展并提高了紫杉醇的敏感性。
在这项研究中，我们鉴定了一种新的circRNA，circ_0002483，并进一步研究了其在NSCLC的进展和紫杉醇抗性中的功能。我们发现circ_0002483在NSCLC组织和细胞系中低水平表达。功能测定表明，circ_0002483过表达显着抑制NSCLC细胞的体外和体内增殖和侵袭，并增强了NSCLC细胞对紫杉醇的敏感性。从机理上讲，鉴定出circ_0002483可以使多种miRNA发生变化，包括miR-182-5p（也称为miR-182），miR-520q-3p，miR-582-3p，miR-587和miR-655。另外，还证明了circ_0002483通过使miR-182-5p变海绵来调节GRB2，FOXO1和FOXO3（miR-182-5p的三个靶标基因）的表达。
更新日期：2019-12-17
中文翻译：
Hsa_circ_0002483通过靶向miR-182-5p抑制非小细胞肺癌的进展并提高了紫杉醇的敏感性。
在这项研究中，我们鉴定了一种新的circRNA，circ_0002483，并进一步研究了其在NSCLC的进展和紫杉醇抗性中的功能。我们发现circ_0002483在NSCLC组织和细胞系中低水平表达。功能测定表明，circ_0002483过表达显着抑制NSCLC细胞的体外和体内增殖和侵袭，并增强了NSCLC细胞对紫杉醇的敏感性。从机理上讲，鉴定出circ_0002483可以使多种miRNA发生变化，包括miR-182-5p（也称为miR-182），miR-520q-3p，miR-582-3p，miR-587和miR-655。另外，还证明了circ_0002483通过使miR-182-5p变海绵来调节GRB2，FOXO1和FOXO3（miR-182-5p的三个靶标基因）的表达。
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