Supplemental Digital Content is available in the text. Although most pregnancies after assisted reproduction are associated with a favorable outcome for the mother and infant, reports of abnormal vascular adaptation in early pregnancy and emerging maternal and perinatal pathology warrant further investigations. Herein we extended our previous work and further examined whether perturbations of blood pressure and endothelial function during the first trimester in conceptions with nonphysiological corpus luteum (CL) numbers would persist through the third trimester of pregnancy and into the postpartum period. We investigated both maternal and perinatal outcomes. Participants were grouped according to CL number and method of conception: 0 CL (programmed autologous frozen-thawed embryo transfer, N=10–18); 1 CL (spontaneous conception [N=16] and natural cycle frozen-thawed embryo transfer [N=12]); or >3 CL associated with autologous fresh embryo transfer [N=8–12]. Augmentation index was higher during the third trimester in the absence of a CL compared to 1 CL (P=0.03) and in frozen-thawed embryo transfer in a programmed compared to a natural cycle (P=0.02). Moreover, baseline pulse-wave amplitude was higher in >3 CL conceptions at all time points (all P<0.05). The incidence of preeclampsia and preeclampsia with severe features was significantly higher in the absence of a CL compared to the presence of one or >3 CL (P=0.045 and P=0.03). Infants from conceptions with >3 CL had lower birth weights (P=0.02) and a higher rate of low birth weight offspring (P=0.008). Deficient vascular adaptation during early gestation in conceptions with nonphysiological CL numbers might predispose women to adverse pregnancy outcomes, for example, preeclampsia.

中文翻译：

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孕期和产后辅助生殖后的母亲血管健康


文本中提供了补充数字内容。尽管辅助生殖后的大多数妊娠都与母亲和婴儿的良好结局相关，但有关妊娠早期异常血管适应以及新出现的孕产妇和围产期病理的报告值得进一步研究。在此，我们扩展了之前的工作，并进一步研究了非生理性黄体（CL）数量的受孕者在妊娠前三个月期间血压和内皮功能的扰动是否会持续到妊娠晚期并进入产后期。我们调查了孕产妇和围产期结局。参与者根据 CL 数量和受孕方法进行分组： 0 CL（程序化自体冻融胚胎移植，N=10-18）； 1 CL（自然受孕[N=16]和自然周期冻融胚胎移植[N=12]）；或 >3 CL 与自体新鲜胚胎移植相关 [N=8–12]。与 1 CL 相比，在没有 CL 的妊娠晚期，扩增指数更高（P=0.03）；与自然周期相比，程序化冻融胚胎移植的扩增指数更高（P=0.02）。此外，在所有时间点，>3 CL 受孕者的基线脉搏波幅度均较高（所有 P<0 id=4>3 CL（P=0.045 和 P=0.03）。>3 CL 受孕的婴儿出生体重较低(P=0.02) 和较高的低出生体重后代率 (P=0.008) 在非生理性 CL 数的妊娠早期血管适应不足可能会使女性容易出现不良妊娠结局，例如先兆子痫。