Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs downstream of inflammasome activation. Pyroptosis is mediated directly by the recently identified family of pore-forming proteins known as gasdermins, the best characterized of which is gasdermin D (GSDMD). Recent investigations implicate pyroptosis in the pathogenesis of multiple neurological diseases. In this review, we discuss molecular mechanisms that drive pyroptosis, evidence for pyroptosis within the CNS, and emerging therapeutic strategies for its inhibition in the context of neurological disease.

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火热细胞死亡：中枢神经系统的细胞焦亡

细胞焦亡（“火热死亡”）是一种炎症类型的调节性细胞死亡 (RCD)，发生在炎症小体激活的下游。细胞焦亡是由最近发现的称为gasdermin 的成孔蛋白家族直接介导的，其中最好的特征是gasdermin D (GSDMD)。最近的研究表明细胞焦亡与多种神经系统疾病的发病机制有关。在这篇综述中，我们讨论了驱动细胞焦亡的分子机制、中枢神经系统内焦亡的证据，以及在神经系统疾病的背景下抑制焦亡的新兴治疗策略。