BACKGROUND Cerebrospinal fluid circulation is crucial for the functioning of the brain. Aging and brain pathologies such as Alzheimer's disease have been associated with a change in the morphology of the ventricles and the choroid plexus. Despite the evidence from animal models that the cerebrospinal fluid system plays an important role in neuroinflammation and the restoration of the brain after ischemic brain injury, little is known about changes to the choroid plexus after stroke in humans. AIMS Our goal was to characterize structural choroid plexus changes poststroke. METHODS We used an automatic segmentation tool to estimate the volumes of choroid plexus and lateral ventricles in stroke and control participants at three time points (at baseline, 3 and 12 months) over the first year after stroke. We assessed group differences cross-sectionally at each time point and longitudinally. For stroke participants, we specifically differentiated between ipsi- and contra-lesional volumes. Statistical analyses were conducted for each region separately and included covariates such as age, sex, total intracranial volume, and years of education. RESULTS We observed significantly larger choroid plexus volumes in stroke participants compared to controls in both cross-sectional and longitudinal analyses. Choroid plexus volumes did not exhibit any change over the first year after stroke, with no difference between ipsi- and contra-lesional volumes. This was in contrast to the volume of lateral ventricles that we found to enlarge over time in all participants, with more accelerated expansion in stroke survivors ipsi-lesionally. CONCLUSIONS Our results suggest that chronic stages of stroke are characterized by larger choroid plexus volumes, but the enlargement likely takes place prior to or very early after the stroke incident.

中文翻译：

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中风后脉络丛神经体积。

背景技术脑脊髓液循环对于脑功能至关重要。诸如阿尔茨海默氏病的衰老和脑部疾病与脑室和脉络丛的形态变化有关。尽管有动物模型的证据表明，脑脊髓液系统在缺血性脑损伤后在神经炎症和大脑恢复中起着重要作用，但人们对中风后脉络丛的变化知之甚少。目的我们的目的是表征卒中后结构性脉络丛神经的变化。方法我们使用自动分割工具来估计卒中后第一年的三个时间点（基线，3和12个月）的卒中和对照组参与者的脉络丛和侧脑室的体积。我们在每个时间点横断面和纵向评估组差异。对于中风参与者，我们专门区分了同病灶和对病灶。对每个地区分别进行统计分析，包括年龄，性别，总颅内体积和受教育年限等协变量。结果我们在横断面和纵向分析中均观察到与对照相比，卒中参与者的脉络丛体积明显更大。卒中后的第一年，脉络丛的体积没有任何变化，同侧和对侧病变体积之间没有差异。与之相反的是，我们发现所有参与者的侧脑室体积都随着时间的推移而增大，而卒中幸存者的同侧病变则加速增长。