当前位置：
X-MOL 学术
›
Nanomed. Nanotech. Biol. Med.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
MKC-Quatsomes: a stable nanovesicle platform for bio-imaging and drug-delivery applications.
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 4.2 ) Pub Date : 2019-12-13 , DOI: 10.1016/j.nano.2019.102136 Guillem Vargas-Nadal 1 , Mónica Muñoz-Úbeda 1 , Patricia Álamo 2 , Montserrat Mitjans 3 , Virtudes Céspedes 4 , Mariana Köber 5 , Elisabet González-Mira 1 , Lidia Ferrer-Tasies 6 , Maria Pilar Vinardell 3 , Ramón Mangues 4 , Jaume Veciana 5 , Nora Ventosa 5
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 4.2 ) Pub Date : 2019-12-13 , DOI: 10.1016/j.nano.2019.102136 Guillem Vargas-Nadal 1 , Mónica Muñoz-Úbeda 1 , Patricia Álamo 2 , Montserrat Mitjans 3 , Virtudes Céspedes 4 , Mariana Köber 5 , Elisabet González-Mira 1 , Lidia Ferrer-Tasies 6 , Maria Pilar Vinardell 3 , Ramón Mangues 4 , Jaume Veciana 5 , Nora Ventosa 5
Affiliation
|
Quatsomes are outstanding new lipid-based nanovesicles that are highly homogeneous and stable in different media for years, but the composition must be carefully chosen to avoid any potentially toxic side effects in in vivo applications. To this end, we have developed and studied a novel type of Quatsomes composed of cholesterol and myristalkonium chloride (MKC), the latter being extensively used as antimicrobial preservative in many ophthalmic and parenteral formulations on the EU and USA market. We have synthesized these novel MKC-Quatsomes in different media that are suitable for parenteral administration, and confirmed their stability in these media for 18 months, as well as the stability in human serum for 24 hours. Biodistribution assays were performed after intravenous injection of fluorescently labeled MKC-Quatsomes in live mice bearing xenografted colorectal tumors, showing nanovesicle accumulation in tumors, liver, spleen, and kidneys. No histological alteration or toxicity was observed in any of these organs.
中文翻译：
MKC-Quatsomes：用于生物成像和药物递送应用的稳定纳米囊泡平台。
脂质体是出色的新型脂质基纳米囊泡，在不同介质中具有多年的均质性和稳定性，但必须谨慎选择其组成，以免在体内应用中产生任何潜在的毒副作用。为此，我们开发并研究了一种由胆固醇和肉豆蔻酰氯（MKC）组成的新型Quatsomes，后者在欧盟和美国市场上的许多眼科和肠胃外制剂中被广泛用作抗菌防腐剂。我们已经在适合肠胃外给药的不同培养基中合成了这些新颖的MKC-Quatsomes，并确认了它们在这些培养基中的稳定性18个月，以及在人血清中的24小时稳定性。在带有异种移植结直肠肿瘤的活小鼠中静脉注射荧光标记的MKC-Quatsomes后，进行了生物分布测定，结果表明纳米囊泡在肿瘤，肝脏，脾脏和肾脏中蓄积。在任何这些器官中均未观察到组织学改变或毒性。
更新日期：2019-12-13
中文翻译：
MKC-Quatsomes：用于生物成像和药物递送应用的稳定纳米囊泡平台。
脂质体是出色的新型脂质基纳米囊泡，在不同介质中具有多年的均质性和稳定性，但必须谨慎选择其组成，以免在体内应用中产生任何潜在的毒副作用。为此，我们开发并研究了一种由胆固醇和肉豆蔻酰氯（MKC）组成的新型Quatsomes，后者在欧盟和美国市场上的许多眼科和肠胃外制剂中被广泛用作抗菌防腐剂。我们已经在适合肠胃外给药的不同培养基中合成了这些新颖的MKC-Quatsomes，并确认了它们在这些培养基中的稳定性18个月，以及在人血清中的24小时稳定性。在带有异种移植结直肠肿瘤的活小鼠中静脉注射荧光标记的MKC-Quatsomes后，进行了生物分布测定，结果表明纳米囊泡在肿瘤，肝脏，脾脏和肾脏中蓄积。在任何这些器官中均未观察到组织学改变或毒性。
京公网安备 11010802027423号