Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients.,Cell Death and Differentiation

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Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients.
Cell Death and Differentiation ( IF 13.7 ) Pub Date : 2019-12-13 , DOI: 10.1038/s41418-019-0474-7
Jean M Mulcahy Levy _{1,

2,

3} , Andrew Thorburn ₃

Affiliation

Autophagy allows for cellular material to be delivered to lysosomes for degradation resulting in basal or stress-induced turnover of cell components that provide energy and macromolecular precursors. These activities are thought to be particularly important in cancer where both tumor-promoting and tumor-inhibiting functions of autophagy have been described. Autophagy has also been intricately linked to apoptosis and programmed cell death, and understanding these interactions is becoming increasingly important in improving cancer therapy and patient outcomes. In this review, we consider how recent discoveries about how autophagy manipulation elicits its effects on cancer cell behavior can be leveraged to improve therapeutic responses.

中文翻译：

癌症中的自噬：从理解机制转向改善患者的治疗反应。

自噬允许细胞物质被递送至溶酶体进行降解，从而导致提供能量和大分子前体的细胞成分的基础或应激诱导的周转。这些活性被认为在癌症中特别重要，其中自噬的肿瘤促进和肿瘤抑制功能均已被描述。自噬还与细胞凋亡和程序性细胞死亡有着复杂的联系，了解这些相互作用对于改善癌症治疗和患者预后变得越来越重要。在这篇综述中，我们考虑如何利用最近关于自噬操纵如何引发其对癌细胞行为的影响的发现来改善治疗反应。

更新日期：2019-12-13

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