The mechanistic target of rapamycin (mTOR) is an essential nutrient-sensing kinase that integrates and regulates a number of fundamental cellular processes required for cell growth, cell motility, translation, metabolism, and autophagy. mTOR signaling has been implicated in the progression of many human diseases, and its dysregulation has been reported in several pathological processes, especially in age-related human diseases and mouse models of accelerated aging. In addition, many studies have demonstrated that the regulation of mTOR activity has a beneficial effect on longevity in several mouse models of aging. However, not all mouse models of accelerated aging show positive effects on aging-associated phenotypes in response to targeting mTOR signaling. Here, we review the effects of interventions that modulate mTOR signaling on aging-related phenotypes in different mouse models of accelerated aging and discuss their implications with respect to aging and aging-related disorders.

中文翻译：

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雷帕霉素信号传导在加速衰老小鼠模型中的机制靶点。

雷帕霉素（mTOR）的机械靶标是一种重要的营养敏感激酶，可整合并调节细胞生长，细胞运动，翻译，代谢和自噬所需的许多基本细胞过程。mTOR信号传导已牵涉到许多人类疾病的进展中，并且其失调在几种病理过程中都有报道，特别是在与年龄有关的人类疾病和加速衰老的小鼠模型中。此外，许多研究表明，在几种衰老小鼠模型中，mTOR活性的调节对寿命有有益的影响。但是，并非所有加速衰老的小鼠模型都对靶向mTOR信号产生反应，对与衰老相关的表型具有积极作用。这里，