Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health.,International Journal of Epidemiology

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Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health.
International Journal of Epidemiology ( IF 6.4 ) Pub Date : 2019-12-13 , DOI: 10.1093/ije/dyz250
Qian Yang _{1,

2} , Louise A C Millard _{1,

2,

3} , George Davey Smith _{1,

2}

Affiliation

A lack of genetic data across generations makes transgenerational Mendelian randomization (MR) difficult. We used UK Biobank and a novel proxy gene-by-environment MR to investigate effects of maternal smoking heaviness in pregnancy on offspring health, using participants’ (generation one: G1) genotype (rs16969968 in CHRNA5) as a proxy for their mothers’ (G0) genotype.

中文翻译：

代理基因-环境孟德尔随机化研究证实了母亲吸烟对后代出生体重的因果影响，但几乎没有证据表明对后代健康有长期影响。

跨代遗传数据的缺乏使得跨代孟德尔随机化 (MR) 变得困难。我们使用 UK Biobank 和一种新的代理基因逐环境 MR 来研究怀孕期间母亲吸烟重度对后代健康的影响，使用参与者的（第一代：G1）基因型（CHRNA5 中的rs16969968）作为他们母亲的代理（ G0) 基因型。

更新日期：2019-12-13

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