Most deaths in Western countries can currently be associated with fibrotic diseases. During fibrosis excessive amounts of extra‐cellular matrix components, such as collagen, are deposited in tissues, which can lead to tissue stiffness and organ failure. The underlying mechanisms leading to tissue fibrosis remain poorly understand and, consequently, our capacities to treat fibrotic diseases remain limited. Currently approved drugs only delay the progression of fibrosis and are often associated with severe side‐effects, which limit their clinical application. Thus, a better understanding of the ontology of fibrotic diseases and the development of more specific and more efficient drugs for the treatment of tissue fibrosis is an urgent clinical meet.

中文翻译：

---

双调蛋白作为组织纤维化的驱动因素。

目前西方国家的大多数死亡可能与纤维化疾病有关。在纤维化过程中，过量的细胞外基质成分（例如胶原蛋白）沉积在组织中，这会导致组织僵硬和器官衰竭。导致组织纤维化的潜在机制仍然知之甚少，因此，我们治疗纤维化疾病的能力仍然有限。目前获批的药物只能延缓纤维化进程，且往往伴有严重的副作用，限制了其临床应用。因此，更好地了解纤维化疾病的本体论，开发更特异、更有效的治疗组织纤维化的药物是临床亟待解决的问题。