BACKGROUND Lipids and adipokines including leptin, resistin and visfatin play various roles in the pathophysiology of Gestational Diabetes Mellitus (GDM). This study was aimed at determining whether serum leptin, resistin and visfatin are significantly altered during the first trimester of pregnancies that subsequently develop GDM and whether such changes are useful in predicting the disease. METHODS This was a case-case control study which compared first trimester biochemical and anthropometric parameters in 70 pregnant women who subsequently developed GDM and 70 pregnant women without GDM at the Volta Regional Hospital, Ho, Ghana. Lipid profile and some selected adipokines were analyzed and first trimester body mass index (BMI) was determined. RESULTS There were significant differences (p < 0.05) in leptin, resistin, and visfatin as well as significant dyslipidemia among those with GDM compared to those without GDM. Furthermore, the area under the Receiver Operating Characteristic Curves (AUCs) for leptin, resistin and visfatin were; 0.812, 0.836 and 0.799 respectively. Increased first trimester leptin (OR = 1.166; CI = 1.104-1.233; p < 0.0001), resistin (p < 0.0001) and visfatin (p < 0.0001) were associated with GDM. CONCLUSION Hyperleptinemia, hyperesistinemia and hypervisfatinemia precede GDM and can serve as good predictive indices for gestational diabetes mellitus.

中文翻译：

---

瘦素，抵抗素和visfatin可作为妊娠糖尿病的有用预测指标。

背景技术脂蛋白和脂肪因子包括瘦蛋白，抵抗素和visfatin在妊娠糖尿病（GDM）的病理生理学中起多种作用。这项研究的目的是确定在怀孕的前三个月中，其血清瘦素，抵抗素和维斯法汀是否发生了显着改变，随后又发展为GDM，以及这种改变是否可用于预测疾病。方法这是一个病例对照研究，在加纳省何安市沃尔特地区医院比较了70名随后发展为GDM的孕妇和70名无GDM的孕妇的早孕生化和人体测量学参数。分析了脂质分布和一些选定的脂肪因子，并确定了孕早期的体重指数（BMI）。结果瘦素，抵抗素，与没有GDM的患者相比，GDM的患者体内的visfatin以及明显的血脂异常。此外，瘦素，抵抗素和visfatin的受体工作特征曲线（AUC）下的面积分别为；分别为0.812、0.836和0.799。妊娠早期瘦素（OR = 1.166; CI = 1.104-1.233; p <0.0001），抵抗素（p <0.0001）和visfatin（p <0.0001）增加与GDM相关。结论高脂血症，高血脂血症和高visfatinatinemia发生在GDM之前，可以作为妊娠糖尿病的良好预测指标。CI = 1.104-1.233；p <0.0001），抵抗素（p <0.0001）和visfatin（p <0.0001）与GDM相关。结论高脂血症，高血脂血症和高visfatinemia发生在GDM之前，可以作为妊娠糖尿病的良好预测指标。CI = 1.104-1.233；p <0.0001），抵抗素（p <0.0001）和visfatin（p <0.0001）与GDM相关。结论高脂血症，高血脂血症和高visfatinatinemia发生在GDM之前，可以作为妊娠糖尿病的良好预测指标。