BACKGROUND Neglected tropical diseases (NTDs) affect more than one billion people living in vulnerable conditions. In spite of initiatives recently contributing to fill NTDs gaps on national and local prevalence and distribution, more epidemiological data are still needed for effective control and elimination interventions. MAIN TEXT Mozambique is considered one of the countries with highest NTDs burden although available data is scarce. This study aims to conduct a systematic review on published available data about the burden and distribution of the different NTDs across Mozambique since January 1950 until December 2018. We identified manuscripts from electronic databases (Pubmed, EmBase and Global Health) and paper publications and grey literature from Mozambique Ministry of Health. Manuscripts fulfilling inclusion criteria were: cross-sectional studies, ecological studies, cohorts, reports, systematic reviews, and narrative reviews capturing epidemiological information of endemic NTDs in Mozambique. Case-control studies, letters to editor, case reports and case series of imported cases were excluded. A total of 466 manuscripts were initially identified and 98 were finally included after the revision following PRISMA guidelines. Eleven NTDs were reported in Mozambique during the study span. Northern provinces (Nampula, Cabo Delgado, Niassa, Tete and Zambezia) and Maputo province had the higher number of NTDs detected. Every disease had their own report profile: while schistosomiasis have been continuously reported since 1952 until nowadays, onchocerciasis and cysticercosis last available data is from 2007 and Echinococcosis have never been evaluated in the country. Thus, both space and time gaps on NTDs epidemiology have been identified. CONCLUSIONS This review assembles NTDs burden and distribution in Mozambique. Thus, contributes to the understanding of NTDs epidemiology in Mozambique and highlights knowledge gaps. Hence, the study provides key elements to progress towards the control and interruption of transmission of these diseases in the country.

中文翻译：

---

莫桑比克被忽视的热带病的频率和分布：系统评价。


背景技术 被忽视的热带病（NTD）影响着超过 10 亿生活在脆弱环境中的人。尽管最近采取了一些举措，有助于填补国家和地方的被忽视热带疾病患病率和分布方面的差距，但仍需要更多的流行病学数据来进行有效的控制和消除干预措施。尽管可用数据很少，但莫桑比克被认为是被忽视热带病负担最高的国家之一。本研究旨在对自 1950 年 1 月至 2018 年 12 月以来莫桑比克各地不同 NTD 的负担和分布的已发表可用数据进行系统回顾。我们从电子数据库（Pubmed、EmBase 和 Global Health）以及纸质出版物和灰色文献中确定了手稿来自莫桑比克卫生部。符合纳入标准的手稿包括：横断面研究、生态研究、队列研究、报告、系统评价和叙述性评论，捕捉莫桑比克地方性 NTD 的流行病学信息。病例对照研究、致编辑的信、病例报告和输入病例的病例系列被排除在外。初步确定了 466 篇稿件，按照 PRISMA 指南修改后最终纳入 98 篇。研究期间莫桑比克报告了 11 种被忽视的热带病。北部省份（楠普拉、德尔加杜角、尼亚萨、太特和赞比西亚）和马普托省检测到的被忽视的热带病数量较多。每种疾病都有自己的报告概况：虽然血吸虫病自1952年至今不断有报告，但盘尾丝虫病和囊尾蚴病的最新数据是在2007年，而包虫病从未在该国进行过评估。因此，NTD 流行病学的空间和时间差距都已确定。 结论 本次审查汇总了莫桑比克被忽视热带病的负担和分布。因此，有助于了解莫桑比克被忽视的热带病流行病学并凸显知识差距。因此，该研究为该国控制和阻断这些疾病的传播提供了关键要素。