BACKGROUND This study aims to investigate the application value of three-dimensional arterial spin labeling (3DASL) in investigating cerebral blood flow dynamics in full-term neonates. METHODS A total of 60 full-term neonates without known intracranial pathology were recruited for 3DASL examination. These neonates were divided into three groups: 1-3 day group, 4-7 day group, and 8-15 day group. On the cerebral blood flow (CBF) images, regions of interest (ROI) were selected from the frontal white matter, parietal white matter, basal ganglia, corona radiata, thalamus and brainstem, and the CBF values of each ROI were recorded. The CBF values of ROIs at bilaterally symmetric locations, the values of each ROI between males and females, and the values of each ROI among these three different age groups were compared. RESULTS The difference in CBF values of the frontal white matter, parietal white matter, basal ganglia, corona radiata and thalamus at the bilateral symmetric positions were not statistically significant. There was no statistical difference in the CBF values of each brain region between the male and female groups. The CBF values at the basal ganglia region, corona radiata and parietal white matter were higher in the 8-15 day group, when compared to the 1-3 day and 4-7 day groups (P < 0.05). The CBF value at the basal ganglia region was higher in the 4-7 day group, when compared to the 1-3 day group (P < 0.05). The CBF value at the frontal white matter was lower in the 4-7 day group, when compared to the 1-3 day and 8-15 day group (P < 0.05). The CBF value at the brainstem was higher in the 4-7 day group, when compared to the 1-3 day and 8-15 day groups (P < 0.05). CONCLUSION The 3DASL can quantitatively measure CBF, and be used to evaluate cerebral hemodynamics in neonates. The basal ganglia region and corona radiata CBF increases with the increase in neonatal diurnal age.

中文翻译：

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三维动脉自旋标记灌注成像在正常足月新生儿脑血流动力学研究中的应用价值。

背景技术本研究旨在探讨三维动脉自旋标记（3DASL）在足月新生儿脑血流动力学研究中的应用价值。方法总共招募了60名没有已知颅内病理学的足月新生儿进行3DASL检查。这些新生儿分为三组：1-3天组，4-7天组和8-15天组。在脑血流（CBF）图像上，从额叶白质，顶叶白质，基底神经节，电晕放射线，丘脑和脑干中选择感兴趣区域（ROI），并记录每个ROI的CBF值。比较了双侧对称位置的ROI的CBF值，男女之间的每个ROI值以及这三个不同年龄组中每个ROI的值。结果额叶白质，顶叶白质，基底神经节，电晕放射线和丘脑的CBF值在双侧对称位置的差异无统计学意义。男性和女性组之间每个大脑区域的CBF值均无统计学差异。与1-3天和4-7天组相比，在8-15天组的基底神经节区域，电晕放射线和顶叶白质的CBF值更高（P <0.05）。与1-3天组相比，在4-7天组的基底神经节区域的CBF值更高（P <0.05）。与1-3天和8-15天组相比，在4-7天组中额叶白质的CBF值较低（P <0.05）。4-7天组脑干的CBF值较高，与1-3天和8-15天组相比（P <0.05）。结论3DASL可以定量测量CBF，可用于评估新生儿的脑血流动力学。随着新生儿昼夜年龄的增加，基底神经节区域和电晕放射线CBF增加。