The role of the microbiota in multiple autoimmune diseases, including juvenile idiopathic arthritis (JIA) has earned substantial attention in the last 10 years. Increasing evidence suggests that the microbiota's link to JIA begins in early childhood, as early life events that influence the nature of the microbiota also appear to influence disease risk. In this review, we discuss these early life events including mode of delivery, infant feeding practice, antibiotics exposure, and other events and their impacts on the microbiota and on disease risk; reported abnormalities of the microbiota in children with JIA; mechanisms by which an altered microbiota at birth and later on in childhood may influence disease risk; and the prospects for therapeutic alteration of the microbiota in children with JIA.

中文翻译：

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幼年特发性关节炎中的微生物乐团：声音混乱吗？

在过去的十年中，微生物群在包括幼年特发性关节炎（JIA）在内的多种自身免疫疾病中的作用已引起广泛关注。越来越多的证据表明，微生物群与JIA的联系始于儿童早期，因为影响微生物群性质的早期生活事件似乎也影响疾病风险。在这篇综述中，我们讨论了这些早期生命事件，包括分娩方式，婴儿喂养实践，抗生素暴露以及其他事件，以及它们对微生物群和疾病风险的影响；报告了JIA儿童的微生物群异常；出生时及儿童期以后微生物群改变的机制可能影响疾病风险；以及JIA儿童中微生物群治疗性改变的前景。