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RhIII -Catalyzed Synthesis of Highly Substituted 2-Pyridones using Fluorinated Diazomalonate.
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2019-12-13 , DOI: 10.1002/asia.201901620 Debapratim Das 1 , Gopal Sahoo 1 , Aniruddha Biswas 1 , Rajarshi Samanta 1
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2019-12-13 , DOI: 10.1002/asia.201901620 Debapratim Das 1 , Gopal Sahoo 1 , Aniruddha Biswas 1 , Rajarshi Samanta 1
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A RhIII -catalyzed strategy was developed for the rapid construction of highly substituted 2-pyridone scaffolds using α,β-unsaturated oximes and fluorinated diazomalonate. The reaction proceeds through direct, site-selective alkylation based on migratory insertion and subsequent cyclocondensation. A wide substrate scope with different functional groups was explored. The requirement of fluorinated diazomalonate was explored for this transformation. The developed methodology was further extended with the synthesis of the bioactive compound.
中文翻译：
RhIII氟化重氮丙二酸酯催化RhIII催化的高取代2-吡啶酮合成。
开发了一种RhIII催化的策略，用于使用α，β-不饱和肟和氟化的重氮丙二酸酯快速构建高度取代的2-吡啶酮骨架。反应基于迁移插入和随后的环缩合通过直接的，位点选择性的烷基化进行。探索了具有不同官能团的广泛底物范围。探究了氟化重氮丙二酸酯对这种转化的需求。随着生物活性化合物的合成，进一步扩展了开发的方法。
更新日期：2020-01-16
中文翻译：
RhIII氟化重氮丙二酸酯催化RhIII催化的高取代2-吡啶酮合成。
开发了一种RhIII催化的策略，用于使用α，β-不饱和肟和氟化的重氮丙二酸酯快速构建高度取代的2-吡啶酮骨架。反应基于迁移插入和随后的环缩合通过直接的，位点选择性的烷基化进行。探索了具有不同官能团的广泛底物范围。探究了氟化重氮丙二酸酯对这种转化的需求。随着生物活性化合物的合成，进一步扩展了开发的方法。
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